The usefulness of C-reactive protein in predicting malaria parasitemia in a sub-Saharan African region
| العنوان: | The usefulness of C-reactive protein in predicting malaria parasitemia in a sub-Saharan African region |
|---|---|
| المؤلفون: | Juergen May, Florian Marks, Nimako Sarpong, Yaw Adu-Sarkodie, Thalea Tamminga, Anna Jaeger, Bismark Osei Sarfo, Andreas Hahn, Norbert Georg Schwarz |
| المساهمون: | Sarfo, Bismark Osei [0000-0002-3264-4578], Apollo - University of Cambridge Repository |
| المصدر: | PLoS ONE PLoS ONE, Vol 13, Iss 8, p e0201693 (2018) |
| بيانات النشر: | Public Library of Science (PLoS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Plasmodium, Endemic Diseases, Quantitative Parasitology, Physiology, lcsh:Medicine, Fevers, Parasitemia, Pathology and Laboratory Medicine, Gastroenterology, 0302 clinical medicine, Medicine and Health Sciences, lcsh:Science, Child, Whole blood, Protozoans, Multidisciplinary, biology, Malarial Parasites, Eukaryota, Prognosis, Body Fluids, Blood film, Blood, C-Reactive Protein, Predictive value of tests, Child, Preschool, Female, Anatomy, Research Article, medicine.medical_specialty, Sub saharan, Adolescent, Fever, 030106 microbiology, 030231 tropical medicine, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Predictive Value of Tests, Internal medicine, Parasite Groups, parasitic diseases, Parasitic Diseases, medicine, Humans, ddc:610, Africa South of the Sahara, Plasmodium species, business.industry, lcsh:R, C-reactive protein, Organisms, Biology and Life Sciences, Septicemia, Infant, Tropical Diseases, medicine.disease, Parasitic Protozoans, Malaria, biology.protein, lcsh:Q, Parasitology, 610 Medizin und Gesundheit, business, Apicomplexa |
| الوصف: | Background: Malaria remains a leading cause of childhood mortality in sub-Saharan Africa. Identifying patients who are at risk for severe manifestations at presentation still remains challenging. This study examines whether a semi-quantitative test on C-Reactive Protein (CRP) could be useful for rapidly predicting the presence or absence of malarial parasitemia in febrile children. Method: Data were collected from children with fever or a history of fever at the Agogo Presbyterian Hospital in the Ashanti Region of Ghana. Haematological measurements, microscopic detection of plasmodium species and semi-quantitative CRP measurements with a membrane–based immunoassay for whole blood were performed. CRP was classified as positive when the measured level was ≥ 10 mg/l. Results: During 548 visits, thick blood film results could be obtained from 541 patients, 270 (49.3%) yielded parasitemia with Plasmodium spp. Whereas malaria parasites were detected in only a few patients (7.1%) with normal CRP levels (< 10mg/l), more than a half of patients with an increased CRP concentration (≥ 10 mg/l) were parasite positive (OR 14.5 [CI 4.4–47.6], p |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1780b694959a533ffb0b1fb0b489eee5 https://www.repository.cam.ac.uk/handle/1810/289681 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1780b694959a533ffb0b1fb0b489eee5 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |