Tumor-infiltrating lymphocytes predict survival outcomes in patients with cervical cancer treated with concurrent chemoradiotherapy

التفاصيل البيبلوغرافية
العنوان: Tumor-infiltrating lymphocytes predict survival outcomes in patients with cervical cancer treated with concurrent chemoradiotherapy
المؤلفون: Hiroshi Nishio, Guanliang Chen, Kohsei Tanaka, Tomonori Yaguchi, Shiho Taniguchi, Yuki Katoh, Masaru Nakamura, Akiko Ohno, Yutaka Kawakami, Takashi Iwata, Tohru Morisada, Miyuki Saito, Daisuke Aoki
المصدر: Gynecologic Oncology. 159:329-334
بيانات النشر: Elsevier BV, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Adult, 0301 basic medicine, Oncology, medicine.medical_specialty, CD3, Uterine Cervical Neoplasms, chemical and pharmacologic phenomena, CD8-Positive T-Lymphocytes, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Internal medicine, Tumor Microenvironment, Carcinoma, Humans, Medicine, Retrospective Studies, Cisplatin, Cervical cancer, Tumor microenvironment, biology, business.industry, Tumor-infiltrating lymphocytes, Obstetrics and Gynecology, FOXP3, hemic and immune systems, Chemoradiotherapy, Middle Aged, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, biology.protein, Female, business, CD8, medicine.drug
الوصف: Objectives To (i) identify correlations between selected immunogenic factors and clinicopathological characteristics, (ii) determine whether intratumoral abundance of various specific tumor-infiltrating lymphocytes (TILs) is a prognostic indicator in women with Stage II and III cervical cancer who undergo treatment with cisplatin-based concurrent chemoradiotherapy (CCRT), and (iii) investigate subtypes of FOXP3+ T cells in 15 fresh samples of cervical cancer. Methods In this retrospective study, intratumoral lesions in colposcopic biopsies from 55 women with advanced cervical cancer who subsequently underwent CCRT at our institution were subjected to automatic immunological staining using the following six mouse monoclonal antibodies: anti-CD3, anti-CD4, anti-CD8, anti-CD20, anti-CD206, and anti-FOXP3. Associations between the findings on automatic scoring of the number of each type of TIL in each specimen and various clinicopathological characteristics were analyzed, as were associations between the abundance of various specific types of TIL and survival. Subtypes of FOXP3+ TILs in 15 additional fresh tumor samples were also investigated using flow cytometry. Results Infiltration with CD8+ TILs was associated with pelvic lymph node metastasis. Abundant infiltration by CD3+, CD4+, CD8+, CD206+, and FOXP3+ TILs were statistically significant indicators of better progression-free and overall survival. Regarding subtypes of FOXP3+ TILs, non-Tregs (Fr-III) were found in all samples tested for this. Conclusions The abundance of various specific intratumoral TILs may be prognostic indicators in patients with advanced cervical cancer undergoing CCRT.
تدمد: 0090-8258
DOI: 10.1016/j.ygyno.2020.07.106
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177be8e1f5b91f21a29a970f481de4ac
https://doi.org/10.1016/j.ygyno.2020.07.106
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....177be8e1f5b91f21a29a970f481de4ac
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00908258
DOI:10.1016/j.ygyno.2020.07.106