American Association for Cancer Research (AACR), 2023.
سنة النشر:
2023
الوصف:
Supplementary Figure 1. Encapsulation efficiency (drug loading/theoretical drug encapsulated) of candidate drugs into PLA-PEG NPs as a function of their solubility in DMSO; Supplementary Figure 2. PLA-PEG NP in vitro stability and uptake; Supplementary Figure 3. in vitro dose-dependent response of HR (L) and mNHEJ (R) pathway repair in the U2OS reporter assay to treatment with either free drug (red) or drug-NP (green) for each candidate radiosentizier; Supplementary Figure 4. dsDNA repair pathway activity levels in U2OS reporter cells; Supplementary Table 1. Results of Linear Regression Analysis and Correlation testing between drug properties and release properties; Supplementary Table 2. Summary of NP-drug formulations and established criteria for candidate drug-NP formulation selection.