Impact of recipient functional status on 1-year liver transplant outcomes
| العنوان: | Impact of recipient functional status on 1-year liver transplant outcomes |
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| المؤلفون: | Natasha H. Dolgin, Paulo N. Martins, Frederick A. Anderson, Adel Bozorgzadeh, Babak Movahedi, Isabel M A Brüggenwirth |
| المصدر: | World Journal of Transplantation World Journal of Transplantation, 9(7), 145-157 |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Transplantation, Graft failure, business.industry, Mortality rate, 030232 urology & nephrology, Graft survival, 030230 surgery, medicine.disease, Confidence interval, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Internal medicine, medicine, Patient survival, Retrospective Cohort Study, Functional status, Risk assessment/risk stratification, business, Severe disability, Clinical decision-making |
| الوصف: | BACKGROUND: The Karnofsky Performance Status (KPS) scale has been widely validated for clinical practice for over 60 years.AIM: To examine the extent to which poor pre-transplant functional status, assessed using the KPS scale, is associated with increased risk of mortality and/or graft failure at 1-year post-transplantation.METHODS: This study included 38278 United States adults who underwent first, non-urgent, liver-only transplantation from 2005 to 2014 (Scientific Registry of Transplant Recipients). Functional impairment/disability was categorized as severe, moderate, or none/normal. Analyses were conducted using multivariable-adjusted Cox survival regression models.RESULTS: The median age was 56 years, 31% were women, median pre-transplant Model for End-Stage for Liver Disease score was 18. Functional impairment was present in 70%; one-quarter of the sample was severely disabled. After controlling for key recipient and donor factors, moderately and severely disabled patients had a 1-year mortality rate of 1.32 [confidence interval (CI): 1.21-1.44] and 1.73 (95%CI: 1.56-1.91) compared to patients with no impairment, respectively. Subjects with moderate and severe disability also had a multivariable-adjusted 1-year graft failure rate of 1.13 (CI: 1.02-1.24) and 1.16 (CI: 1.02-1.31), respectively.CONCLUSION: Pre-transplant functional status is a useful prognostic indicator for 1-year post-transplant patient and graft survival. |
| وصف الملف: | application/pdf |
| تدمد: | 2220-3230 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168c0ee39304381fb30f1cb79e0477c8 https://pubmed.ncbi.nlm.nih.gov/31850158 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....168c0ee39304381fb30f1cb79e0477c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22203230 |
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