أعرض في EDS

Horizontally acquired papGII-containing pathogenicity islands underlie the emergence of invasive uropathogenic Escherichia coli lineages

التفاصيل البيبلوغرافية
العنوان: Horizontally acquired papGII-containing pathogenicity islands underlie the emergence of invasive uropathogenic Escherichia coli lineages
المؤلفون: Veerle Matheeussen, James R. Johnson, Niels Frimodt-Møller, Karen Leth Nielsen, Michael Biggel, Herman Goossens, Pieter Moons, Sandra Van Puyvelde, Basil Britto Xavier
المساهمون: Biggel, Michael [0000-0002-1337-2132], Xavier, Basil B [0000-0002-5897-0240], Nielsen, Karen L [0000-0002-7912-1985], Matheeussen, Veerle [0000-0002-7217-3643], Van Puyvelde, Sandra [0000-0001-8434-5732], Apollo - University of Cambridge Repository
المصدر: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications
بيانات النشر: Springer Science and Business Media LLC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: 0301 basic medicine, General Physics and Astronomy, Genome-wide association study, urologic and male genital diseases, medicine.disease_cause, Bacterial genetics, Uropathogenic Escherichia coli, Urinary Tract, Pathogen, Escherichia coli Infections, Phylogeny, Adhesins, Escherichia coli, Urinary tract infection, education.field_of_study, Multidisciplinary, female genital diseases and pregnancy complications, 3. Good health, Urinary Tract Infections, Engineering sciences. Technology, DNA, Bacterial, Gene Transfer, Horizontal, Genomic Islands, Virulence Factors, Science, 030106 microbiology, Population, Locus (genetics), Biology, Article, General Biochemistry, Genetics and Molecular Biology, Microbiology, 03 medical and health sciences, Phylogenetics, medicine, Humans, Clinical microbiology, education, Escherichia coli, General Chemistry, bacterial infections and mycoses, medicine.disease, Pathogenicity island, 030104 developmental biology, Fimbriae, Bacterial, Bacteremia, bacteria, Bacterial infection, Genome, Bacterial, Genome-Wide Association Study
الوصف: Escherichia coli is the leading cause of urinary tract infection, one of the most common bacterial infections in humans. Despite this, a genomic perspective is lacking regarding the phylogenetic distribution of isolates associated with different clinical syndromes. Here, we present a large-scale phylogenomic analysis of a spatiotemporally and clinically diverse set of 907 E. coli isolates, including 722 uropathogenic E. coli (UPEC) isolates. A genome-wide association approach identifies the (P-fimbriae-encoding) papGII locus as the key feature distinguishing invasive UPEC, defined as isolates associated with severe UTI, i.e., kidney infection (pyelonephritis) or urinary-source bacteremia, from non-invasive UPEC, defined as isolates associated with asymptomatic bacteriuria or bladder infection (cystitis). Within the E. coli population, distinct invasive UPEC lineages emerged through repeated horizontal acquisition of diverse papGII-containing pathogenicity islands. Our findings elucidate the molecular determinants of severe UTI and have implications for the early detection of this pathogen.
Escherichia coli is a major cause of urinary tract infection. Here, Biggel et al. provide a phylogenomic analysis of 907 clinical E. coli isolates and identify the P-fimbriae-encoding locus associated with invasive uropathogenic E. coli isolates.
وصف الملف: application/pdf
تدمد: 2041-1723
DOI: 10.1038/s41467-020-19714-9
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1660f8a89bf635a530d679a5b5a34ed7
https://doi.org/10.1038/s41467-020-19714-9
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....1660f8a89bf635a530d679a5b5a34ed7
قاعدة البيانات: OpenAIRE
ResultId 1
Header edsair
OpenAIRE
edsair.doi.dedup.....1660f8a89bf635a530d679a5b5a34ed7
845
3

unknown
844.75244140625
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....1660f8a89bf635a530d679a5b5a34ed7&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1660f8a89bf635a530d679a5b5a34ed7# [Name] => EDS - OpenAIRE [Category] => fullText [Text] => View record in OpenAIRE [MouseOverText] => View record in OpenAIRE ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Horizontally acquired papGII-containing pathogenicity islands underlie the emergence of invasive uropathogenic Escherichia coli lineages )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Veerle+Matheeussen%22">Veerle Matheeussen</searchLink><br /><searchLink fieldCode="AR" term="%22James+R%2E+Johnson%22">James R. Johnson</searchLink><br /><searchLink fieldCode="AR" term="%22Niels+Frimodt-Møller%22">Niels Frimodt-Møller</searchLink><br /><searchLink fieldCode="AR" term="%22Karen+Leth+Nielsen%22">Karen Leth Nielsen</searchLink><br /><searchLink fieldCode="AR" term="%22Michael+Biggel%22">Michael Biggel</searchLink><br /><searchLink fieldCode="AR" term="%22Herman+Goossens%22">Herman Goossens</searchLink><br /><searchLink fieldCode="AR" term="%22Pieter+Moons%22">Pieter Moons</searchLink><br /><searchLink fieldCode="AR" term="%22Sandra+Van+Puyvelde%22">Sandra Van Puyvelde</searchLink><br /><searchLink fieldCode="AR" term="%22Basil+Britto+Xavier%22">Basil Britto Xavier</searchLink> )
Array ( [Name] => Author [Label] => Contributors [Group] => Au [Data] => Biggel, Michael [0000-0002-1337-2132]<br />Xavier, Basil B [0000-0002-5897-0240]<br />Nielsen, Karen L [0000-0002-7912-1985]<br />Matheeussen, Veerle [0000-0002-7217-3643]<br />Van Puyvelde, Sandra [0000-0001-8434-5732]<br />Apollo - University of Cambridge Repository )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Nature Communications<br />Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)<br />Nature communications )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Springer Science and Business Media LLC, 2020. )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2020 )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%220301+basic+medicine%22">0301 basic medicine</searchLink><br /><searchLink fieldCode="DE" term="%22General+Physics+and+Astronomy%22">General Physics and Astronomy</searchLink><br /><searchLink fieldCode="DE" term="%22Genome-wide+association+study%22">Genome-wide association study</searchLink><br /><searchLink fieldCode="DE" term="%22urologic+and+male+genital+diseases%22">urologic and male genital diseases</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%5Fcause%22">medicine.disease_cause</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+genetics%22">Bacterial genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Uropathogenic+Escherichia+coli%22">Uropathogenic Escherichia coli</searchLink><br /><searchLink fieldCode="DE" term="%22Urinary+Tract%22">Urinary Tract</searchLink><br /><searchLink fieldCode="DE" term="%22Pathogen%22">Pathogen</searchLink><br /><searchLink fieldCode="DE" term="%22Escherichia+coli+Infections%22">Escherichia coli Infections</searchLink><br /><searchLink fieldCode="DE" term="%22Phylogeny%22">Phylogeny</searchLink><br /><searchLink fieldCode="DE" term="%22Adhesins%2C+Escherichia+coli%22">Adhesins, Escherichia coli</searchLink><br /><searchLink fieldCode="DE" term="%22Urinary+tract+infection%22">Urinary tract infection</searchLink><br /><searchLink fieldCode="DE" term="%22education%2Efield%5Fof%5Fstudy%22">education.field_of_study</searchLink><br /><searchLink fieldCode="DE" term="%22Multidisciplinary%22">Multidisciplinary</searchLink><br /><searchLink fieldCode="DE" term="%22female+genital+diseases+and+pregnancy+complications%22">female genital diseases and pregnancy complications</searchLink><br /><searchLink fieldCode="DE" term="%223%2E+Good+health%22">3. Good health</searchLink><br /><searchLink fieldCode="DE" term="%22Urinary+Tract+Infections%22">Urinary Tract Infections</searchLink><br /><searchLink fieldCode="DE" term="%22Engineering+sciences%2E+Technology%22">Engineering sciences. Technology</searchLink><br /><searchLink fieldCode="DE" term="%22DNA%2C+Bacterial%22">DNA, Bacterial</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+Transfer%2C+Horizontal%22">Gene Transfer, Horizontal</searchLink><br /><searchLink fieldCode="DE" term="%22Genomic+Islands%22">Genomic Islands</searchLink><br /><searchLink fieldCode="DE" term="%22Virulence+Factors%22">Virulence Factors</searchLink><br /><searchLink fieldCode="DE" term="%22Science%22">Science</searchLink><br /><searchLink fieldCode="DE" term="%22030106+microbiology%22">030106 microbiology</searchLink><br /><searchLink fieldCode="DE" term="%22Population%22">Population</searchLink><br /><searchLink fieldCode="DE" term="%22Locus+%28genetics%29%22">Locus (genetics)</searchLink><br /><searchLink fieldCode="DE" term="%22Biology%22">Biology</searchLink><br /><searchLink fieldCode="DE" term="%22Article%22">Article</searchLink><br /><searchLink fieldCode="DE" term="%22General+Biochemistry%2C+Genetics+and+Molecular+Biology%22">General Biochemistry, Genetics and Molecular Biology</searchLink><br /><searchLink fieldCode="DE" term="%22Microbiology%22">Microbiology</searchLink><br /><searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Phylogenetics%22">Phylogenetics</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+microbiology%22">Clinical microbiology</searchLink><br /><searchLink fieldCode="DE" term="%22education%22">education</searchLink><br /><searchLink fieldCode="DE" term="%22Escherichia+coli%22">Escherichia coli</searchLink><br /><searchLink fieldCode="DE" term="%22General+Chemistry%22">General Chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22bacterial+infections+and+mycoses%22">bacterial infections and mycoses</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22Pathogenicity+island%22">Pathogenicity island</searchLink><br /><searchLink fieldCode="DE" term="%22030104+developmental+biology%22">030104 developmental biology</searchLink><br /><searchLink fieldCode="DE" term="%22Fimbriae%2C+Bacterial%22">Fimbriae, Bacterial</searchLink><br /><searchLink fieldCode="DE" term="%22Bacteremia%22">Bacteremia</searchLink><br /><searchLink fieldCode="DE" term="%22bacteria%22">bacteria</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+infection%22">Bacterial infection</searchLink><br /><searchLink fieldCode="DE" term="%22Genome%2C+Bacterial%22">Genome, Bacterial</searchLink><br /><searchLink fieldCode="DE" term="%22Genome-Wide+Association+Study%22">Genome-Wide Association Study</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Escherichia coli is the leading cause of urinary tract infection, one of the most common bacterial infections in humans. Despite this, a genomic perspective is lacking regarding the phylogenetic distribution of isolates associated with different clinical syndromes. Here, we present a large-scale phylogenomic analysis of a spatiotemporally and clinically diverse set of 907 E. coli isolates, including 722 uropathogenic E. coli (UPEC) isolates. A genome-wide association approach identifies the (P-fimbriae-encoding) papGII locus as the key feature distinguishing invasive UPEC, defined as isolates associated with severe UTI, i.e., kidney infection (pyelonephritis) or urinary-source bacteremia, from non-invasive UPEC, defined as isolates associated with asymptomatic bacteriuria or bladder infection (cystitis). Within the E. coli population, distinct invasive UPEC lineages emerged through repeated horizontal acquisition of diverse papGII-containing pathogenicity islands. Our findings elucidate the molecular determinants of severe UTI and have implications for the early detection of this pathogen.<br />Escherichia coli is a major cause of urinary tract infection. Here, Biggel et al. provide a phylogenomic analysis of 907 clinical E. coli isolates and identify the P-fimbriae-encoding locus associated with invasive uropathogenic E. coli isolates. )
Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => application/pdf )
Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2041-1723 )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1038/s41467-020-19714-9 )
Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1660f8a89bf635a530d679a5b5a34ed7" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1660f8a89bf635a530d679a5b5a34ed7</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1038/s41467-020-19714-9" linkWindow="_blank">https://doi.org/10.1038/s41467-020-19714-9</link> )
Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....1660f8a89bf635a530d679a5b5a34ed7 )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.1038/s41467-020-19714-9 ) ) [Languages] => Array ( [0] => Array ( [Text] => Undetermined ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => 0301 basic medicine [Type] => general ) [1] => Array ( [SubjectFull] => General Physics and Astronomy [Type] => general ) [2] => Array ( [SubjectFull] => Genome-wide association study [Type] => general ) [3] => Array ( [SubjectFull] => urologic and male genital diseases [Type] => general ) [4] => Array ( [SubjectFull] => medicine.disease_cause [Type] => general ) [5] => Array ( [SubjectFull] => Bacterial genetics [Type] => general ) [6] => Array ( [SubjectFull] => Uropathogenic Escherichia coli [Type] => general ) [7] => Array ( [SubjectFull] => Urinary Tract [Type] => general ) [8] => Array ( [SubjectFull] => Pathogen [Type] => general ) [9] => Array ( [SubjectFull] => Escherichia coli Infections [Type] => general ) [10] => Array ( [SubjectFull] => Phylogeny [Type] => general ) [11] => Array ( [SubjectFull] => Adhesins, Escherichia coli [Type] => general ) [12] => Array ( [SubjectFull] => Urinary tract infection [Type] => general ) [13] => Array ( [SubjectFull] => education.field_of_study [Type] => general ) [14] => Array ( [SubjectFull] => Multidisciplinary [Type] => general ) [15] => Array ( [SubjectFull] => female genital diseases and pregnancy complications [Type] => general ) [16] => Array ( [SubjectFull] => 3. Good health [Type] => general ) [17] => Array ( [SubjectFull] => Urinary Tract Infections [Type] => general ) [18] => Array ( [SubjectFull] => Engineering sciences. Technology [Type] => general ) [19] => Array ( [SubjectFull] => DNA, Bacterial [Type] => general ) [20] => Array ( [SubjectFull] => Gene Transfer, Horizontal [Type] => general ) [21] => Array ( [SubjectFull] => Genomic Islands [Type] => general ) [22] => Array ( [SubjectFull] => Virulence Factors [Type] => general ) [23] => Array ( [SubjectFull] => Science [Type] => general ) [24] => Array ( [SubjectFull] => 030106 microbiology [Type] => general ) [25] => Array ( [SubjectFull] => Population [Type] => general ) [26] => Array ( [SubjectFull] => Locus (genetics) [Type] => general ) [27] => Array ( [SubjectFull] => Biology [Type] => general ) [28] => Array ( [SubjectFull] => Article [Type] => general ) [29] => Array ( [SubjectFull] => General Biochemistry, Genetics and Molecular Biology [Type] => general ) [30] => Array ( [SubjectFull] => Microbiology [Type] => general ) [31] => Array ( [SubjectFull] => 03 medical and health sciences [Type] => general ) [32] => Array ( [SubjectFull] => Phylogenetics [Type] => general ) [33] => Array ( [SubjectFull] => medicine [Type] => general ) [34] => Array ( [SubjectFull] => Humans [Type] => general ) [35] => Array ( [SubjectFull] => Clinical microbiology [Type] => general ) [36] => Array ( [SubjectFull] => education [Type] => general ) [37] => Array ( [SubjectFull] => Escherichia coli [Type] => general ) [38] => Array ( [SubjectFull] => General Chemistry [Type] => general ) [39] => Array ( [SubjectFull] => bacterial infections and mycoses [Type] => general ) [40] => Array ( [SubjectFull] => medicine.disease [Type] => general ) [41] => Array ( [SubjectFull] => Pathogenicity island [Type] => general ) [42] => Array ( [SubjectFull] => 030104 developmental biology [Type] => general ) [43] => Array ( [SubjectFull] => Fimbriae, Bacterial [Type] => general ) [44] => Array ( [SubjectFull] => Bacteremia [Type] => general ) [45] => Array ( [SubjectFull] => bacteria [Type] => general ) [46] => Array ( [SubjectFull] => Bacterial infection [Type] => general ) [47] => Array ( [SubjectFull] => Genome, Bacterial [Type] => general ) [48] => Array ( [SubjectFull] => Genome-Wide Association Study [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Horizontally acquired papGII-containing pathogenicity islands underlie the emergence of invasive uropathogenic Escherichia coli lineages [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Veerle Matheeussen ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => James R. Johnson ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Niels Frimodt-Møller ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Karen Leth Nielsen ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Michael Biggel ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Herman Goossens ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Pieter Moons ) ) ) [7] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Sandra Van Puyvelde ) ) ) [8] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Basil Britto Xavier ) ) ) [9] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Biggel, Michael [0000-0002-1337-2132] ) ) ) [10] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Xavier, Basil B [0000-0002-5897-0240] ) ) ) [11] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Nielsen, Karen L [0000-0002-7912-1985] ) ) ) [12] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Matheeussen, Veerle [0000-0002-7217-3643] ) ) ) [13] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Van Puyvelde, Sandra [0000-0001-8434-5732] ) ) ) [14] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Apollo - University of Cambridge Repository ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 24 [M] => 11 [Type] => published [Y] => 2020 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 20411723 ) [1] => Array ( [Type] => issn-locals [Value] => edsair ) [2] => Array ( [Type] => issn-locals [Value] => edsairFT ) ) [Numbering] => Array ( [0] => Array ( [Type] => volume [Value] => 11 ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Nature Communications [Type] => main ) ) ) ) ) ) )
IllustrationInfo