Horizontally acquired papGII-containing pathogenicity islands underlie the emergence of invasive uropathogenic Escherichia coli lineages
| العنوان: | Horizontally acquired papGII-containing pathogenicity islands underlie the emergence of invasive uropathogenic Escherichia coli lineages |
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| المؤلفون: | Veerle Matheeussen, James R. Johnson, Niels Frimodt-Møller, Karen Leth Nielsen, Michael Biggel, Herman Goossens, Pieter Moons, Sandra Van Puyvelde, Basil Britto Xavier |
| المساهمون: | Biggel, Michael [0000-0002-1337-2132], Xavier, Basil B [0000-0002-5897-0240], Nielsen, Karen L [0000-0002-7912-1985], Matheeussen, Veerle [0000-0002-7217-3643], Van Puyvelde, Sandra [0000-0001-8434-5732], Apollo - University of Cambridge Repository |
| المصدر: | Nature Communications Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020) Nature communications |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, General Physics and Astronomy, Genome-wide association study, urologic and male genital diseases, medicine.disease_cause, Bacterial genetics, Uropathogenic Escherichia coli, Urinary Tract, Pathogen, Escherichia coli Infections, Phylogeny, Adhesins, Escherichia coli, Urinary tract infection, education.field_of_study, Multidisciplinary, female genital diseases and pregnancy complications, 3. Good health, Urinary Tract Infections, Engineering sciences. Technology, DNA, Bacterial, Gene Transfer, Horizontal, Genomic Islands, Virulence Factors, Science, 030106 microbiology, Population, Locus (genetics), Biology, Article, General Biochemistry, Genetics and Molecular Biology, Microbiology, 03 medical and health sciences, Phylogenetics, medicine, Humans, Clinical microbiology, education, Escherichia coli, General Chemistry, bacterial infections and mycoses, medicine.disease, Pathogenicity island, 030104 developmental biology, Fimbriae, Bacterial, Bacteremia, bacteria, Bacterial infection, Genome, Bacterial, Genome-Wide Association Study |
| الوصف: | Escherichia coli is the leading cause of urinary tract infection, one of the most common bacterial infections in humans. Despite this, a genomic perspective is lacking regarding the phylogenetic distribution of isolates associated with different clinical syndromes. Here, we present a large-scale phylogenomic analysis of a spatiotemporally and clinically diverse set of 907 E. coli isolates, including 722 uropathogenic E. coli (UPEC) isolates. A genome-wide association approach identifies the (P-fimbriae-encoding) papGII locus as the key feature distinguishing invasive UPEC, defined as isolates associated with severe UTI, i.e., kidney infection (pyelonephritis) or urinary-source bacteremia, from non-invasive UPEC, defined as isolates associated with asymptomatic bacteriuria or bladder infection (cystitis). Within the E. coli population, distinct invasive UPEC lineages emerged through repeated horizontal acquisition of diverse papGII-containing pathogenicity islands. Our findings elucidate the molecular determinants of severe UTI and have implications for the early detection of this pathogen. Escherichia coli is a major cause of urinary tract infection. Here, Biggel et al. provide a phylogenomic analysis of 907 clinical E. coli isolates and identify the P-fimbriae-encoding locus associated with invasive uropathogenic E. coli isolates. |
| وصف الملف: | application/pdf |
| تدمد: | 2041-1723 |
| DOI: | 10.1038/s41467-020-19714-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1660f8a89bf635a530d679a5b5a34ed7 https://doi.org/10.1038/s41467-020-19714-9 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1660f8a89bf635a530d679a5b5a34ed7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-020-19714-9 |