Unequal nondisjunction frequencies of trivalent chromosomes in male mice heterozygous for two Robertsonian translocations
| العنوان: | Unequal nondisjunction frequencies of trivalent chromosomes in male mice heterozygous for two Robertsonian translocations |
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| المؤلفون: | Heinz Winking, H. Bostelmann, C. Reuter |
| المصدر: | Cytogenetic and Genome Research. 91:303-306 |
| بيانات النشر: | S. Karger AG, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Male, Heterozygote, Chromosomal translocation, Biology, Chromosomes, Translocation, Genetic, Loss of heterozygosity, Mice, Prophase, Gene Frequency, Nondisjunction, Genetic, Meiosis, Genetics, Animals, Kinetochores, Molecular Biology, Genetics (clinical), Anaphase, Synaptonemal Complex, Kinetochore, Chromosome, Molecular biology, Chromosome Banding, Microscopy, Electron, Nondisjunction, Karyotyping |
| الوصف: | Robertsonian (Rb) translocation heterozygosity may cause pairing problems during prophase and segregation irregularities at anaphase of meiosis I. These stages of meiosis I were studied in male mice doubly heterozygous for the two Rb chromosomes Rb(9.19)163H and Rb(16.17)8Lub. At pachytene both Rb chromosomes similarly showed pairing irregularities like unpaired segments. However, highly different nondisjunction frequencies of chromosomes forming the respective trivalents were found. The nondisjunction frequency of the Rb8Lub trivalent chromosomes was about 40%, whereas a very low frequency of nondisjunction was found in combination with the Rb163H trivalent. Since both trivalents were together in the same cell, differences in kinetochore function are assumed to be responsible for the diverse frequency of nondisjunction. |
| تدمد: | 1424-859X 1424-8581 |
| DOI: | 10.1159/000056862 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1618e5dd601c5a15d57f65aaab606393 https://doi.org/10.1159/000056862 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1618e5dd601c5a15d57f65aaab606393 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1424859X 14248581 |
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| DOI: | 10.1159/000056862 |