Cornea Preservation Time Study: Methods and Potential Impact on the Cornea Donor Pool in the United States
| العنوان: | Cornea Preservation Time Study: Methods and Potential Impact on the Cornea Donor Pool in the United States |
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| المؤلفون: | Mark A. Terry, Steven P. Dunn, Jonathan H. Lass, Allison R Ayala, Kevin W. Ross, Beth Ann Benetz, David D. Verdier, Ty L. McCall, Anthony J. Aldave, George O D Rosenwasser, Michelle M. Corrigan, Loretta B Szczotka-Flynn, Sudeep Pramanik, Robin L. Gal |
| المصدر: | Cornea |
| بيانات النشر: | Cornea, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Time Factors, Descemet membrane, Corneal Pachymetry, Cell Count, Eye Banks, 0302 clinical medicine, Cornea, Corneal pachymetry, Child, Donor pool, Potential impact, medicine.diagnostic_test, Corneal Edema, Endothelium, Corneal, Graft Survival, Organ Preservation, Clinical Science, Middle Aged, Descemet stripping automated endothelial keratoplasty, Tissue Donors, 3. Good health, medicine.anatomical_structure, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, preservation time, Adult, Adolescent, 03 medical and health sciences, Study methods, Corneal edema, cornea, medicine, Humans, Descemet Membrane, Intraocular Pressure, Aged, Cryopreservation, business.industry, Fuchs' Endothelial Dystrophy, Transplant Recipients, United States, Ophthalmology, 030221 ophthalmology & optometry, Optometry, sense organs, business, 030217 neurology & neurosurgery, Descemet Stripping Endothelial Keratoplasty |
| الوصف: | Supplemental Digital Content is Available in the Text. Purpose: The aim of this study was to describe the aims, methods, donor and recipient cohort characteristics, and potential impact of the Cornea Preservation Time Study (CPTS). Methods: The CPTS is a randomized clinical trial conducted at 40 clinical sites (70 surgeons) designed to assess the effect of donor cornea preservation time (PT) on graft survival 3 years after Descemet stripping automated endothelial keratoplasty (DSAEK). Eyes undergoing surgery for Fuchs endothelial corneal dystrophy or pseudophakic/aphakic corneal edema were randomized to receive donor corneas stored ≤7 days or 8 to 14 days. Donor and patient characteristics, tissue preparation and surgical parameters, recipient and donor corneal stroma clarity, central corneal thickness, intraocular pressure, complications, and a reading center-determined central endothelial cell density were collected. Surveys were conducted to evaluate pre-CPTS PT practices. Results: The 1330 CPTS donors were: 49% >60 years old, 27% diabetic, had a median eye bank–determined screening endothelial cell density of 2688 cells/mm2, and 74% eye bank prepared for DSAEK. A total of 1090 recipients (1330 eyes including 240 bilateral cases) had: median age of 70 years, were 60% female, 90% white, 18% diabetic, 52% phakic, and 94% had Fuchs endothelial corneal dystrophy. Before the CPTS, 19 eye banks provided PT data on 20,852 corneas domestically placed for DSAEK in 2010 to 2011; 96% were preserved ≤7 days. Of 305 American Academy of Ophthalmology members responding to a pre-CPTS survey, 233 (76%) set their maximum PT preference at 8 days or less. Conclusions: The CPTS will increase understanding of factors related to DSAEK success and, if noninferiority of longer PT is shown, will have great potential to extend the available pool of endothelial keratoplasty donors. Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01537393. |
| اللغة: | English |
| تدمد: | 1536-4798 0277-3740 0153-7393 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e5e44b851a97354b4890293f77ce38 http://europepmc.org/articles/PMC4426012 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....15e5e44b851a97354b4890293f77ce38 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15364798 02773740 01537393 |
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