Risk of fractures associated with treatment for benign prostate hyperplasia in men
| العنوان: | Risk of fractures associated with treatment for benign prostate hyperplasia in men |
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| المؤلفون: | Lars Rejnmark, L. Mosekilde, P. Vestergaard |
| المصدر: | Vestergaard, P, Rejnmark, L & Mosekilde, L 2011, ' Risk of fractures associated with treatment for benign prostate hyperplasia in men ', Osteoporosis International, vol. 22, no. 2, pp. 731-7 . https://doi.org/10.1007/s00198-010-1320-4 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Osteoporosis, Prostatic Hyperplasia, 5-alpha Reductase Inhibitors, Forearm, Risk Factors, Internal medicine, medicine, Humans, Adrenergic alpha-Antagonists, Aged, Aged, 80 and over, Presyncope, Hip Fractures, business.industry, Confounding, Forearm Injuries, Hyperplasia, medicine.disease, Rheumatology, Surgery, Treatment Outcome, medicine.anatomical_structure, Blood pressure, Case-Control Studies, Orthopedic surgery, Spinal Fractures, business |
| الوصف: | Treatment of benign prostate hyperplasia with α-blockers may affect blood pressure while treatment with 5-α-reductase inhibitors may affect conversion of testosterone potentially leading to osteoporosis. In our study, neither 5-α-reductase inhibitors nor α-blockers were associated with negative effects on fractures, α-blockers perhaps being associated with a limited decrease in fractures. The objective is to study fracture risk associated with drugs for benign prostate hyperplasia. The hypotheses were that (1) α-blockers may elevate fracture risk by causing presyncope/falls and (2) 5-α-reductase inhibitors may elevate fracture risk by lowering dihydrotestosterone. This is a nationwide case-control study using all 9,719 male fracture patients aged ≥60 years in the year 2000 as cases and drawing 29,156 age- and gender-matched controls. The main exposure was the use of the drugs mentioned above for benign prostate hyperplasia. Confounder control included social variables, contacts to hospitals and general practitioners, alcoholism and other variables. For the 5-α-reductase inhibitors, no change in overall risk of fractures was seen. No change in risk of hip, spine and forearm fractures was present. For the α-blockers, a decrease in overall risk of fractures was seen, as well as a decrease in the risk of hip and spine fractures, but only at average doses >0.5 defined daily doses per day. No decrease was seen for forearm fractures. A decreasing risk of any fracture, hip fractures and spine fractures were seen with increasing dose of α-blockers, while no such association was seen for the forearm fractures. Neither the 5-α-reductase inhibitors nor α-blockers were associated with negative effects on fracture risk. A small trend towards a decrease in fracture risk may be present for the α-blockers. However, more research is needed to confirm if this trend is real. |
| تدمد: | 1433-2965 0937-941X |
| DOI: | 10.1007/s00198-010-1320-4 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a2636c4fc89dda9c051afc0af9f63a https://doi.org/10.1007/s00198-010-1320-4 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....15a2636c4fc89dda9c051afc0af9f63a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14332965 0937941X |
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| DOI: | 10.1007/s00198-010-1320-4 |