In Vivo Based Fluid–Structure Interaction Biomechanics of the Left Anterior Descending Coronary Artery
| العنوان: | In Vivo Based Fluid–Structure Interaction Biomechanics of the Left Anterior Descending Coronary Artery |
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| المؤلفون: | Anthony C. Zander, H. J. Carpenter, Alireza Gholipour, Peter J. Psaltis, Mergen H. Ghayesh |
| المصدر: | Journal of Biomechanical Engineering. 143 |
| بيانات النشر: | ASME International, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Contraction (grammar), medicine.diagnostic_test, business.industry, 0206 medical engineering, Biomedical Engineering, Biomechanics, 02 engineering and technology, 030204 cardiovascular system & hematology, Anterior Descending Coronary Artery, Coronary Vessels, 020601 biomedical engineering, Coronary arteries, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Ventricle, Physiology (medical), Internal medicine, Angiography, Cardiology, Shear stress, Medicine, business, Artery |
| الوصف: | A fluid–structure interaction-based biomechanical model of the entire left anterior descending coronary artery is developed from in vivo imaging via the finite element method in this paper. Included in this investigation is ventricle contraction, three-dimensional motion, all angiographically visible side branches, hyper/viscoelastic artery layers, non-Newtonian and pulsatile blood flow, and the out-of-phase nature of blood velocity and pressure. The fluid–structure interaction model is based on in vivo angiography of an elite athlete's entire left anterior descending coronary artery where the influence of including all alternating side branches and the dynamical contraction of the ventricle is investigated for the first time. Results show the omission of side branches result in a 350% increase in peak wall shear stress and a 54% decrease in von Mises stress. Peak von Mises stress is underestimated by up to 80% when excluding ventricle contraction and further alterations in oscillatory shear indices are seen, which provide an indication of flow reversal and has been linked to atherosclerosis localization. Animations of key results are also provided within a video abstract. We anticipate that this model and results can be used as a basis for our understanding of the interaction between coronary and myocardium biomechanics. It is hoped that further investigations could include the passive and active components of the myocardium to further replicate in vivo mechanics and lead to an understanding of the influence of cardiac abnormalities, such as arrythmia, on coronary biomechanical responses. |
| تدمد: | 1528-8951 0148-0731 |
| DOI: | 10.1115/1.4050540 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cdb63965863a9a41b00d6c2ed08a50 https://doi.org/10.1115/1.4050540 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....14cdb63965863a9a41b00d6c2ed08a50 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15288951 01480731 |
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| DOI: | 10.1115/1.4050540 |