Neonatal and maternal platelet cytosolic calcium in normotensive and hypertensive pregnancies
| العنوان: | Neonatal and maternal platelet cytosolic calcium in normotensive and hypertensive pregnancies |
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| المؤلفون: | E. M. Symonds, F. Broughton Pipkin, M. D. Kilby |
| المصدر: | Archives of Disease in Childhood - Fetal and Neonatal Edition. 71:F6-10 |
| بيانات النشر: | BMJ, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Adult, Blood Platelets, Gestational hypertension, medicine.medical_specialty, media_common.quotation_subject, Pregnancy Complications, Cardiovascular, Pregnancy, Internal medicine, Placenta, Follicular phase, medicine, Humans, Prospective Studies, Menstrual cycle, media_common, Proteinuria, Platelet Count, business.industry, Obstetrics and Gynecology, General Medicine, Venous blood, Fetal Blood, medicine.disease, Endocrinology, medicine.anatomical_structure, Hypertension, Pediatrics, Perinatology and Child Health, Gestation, Calcium, Female, medicine.symptom, business, Research Article |
| الوصف: | A prospective study investigated platelet cytosolic calcium in non-pregnant volunteers (n = 30) and samples from the umbilical veins of babies from both normotensive (n = 18) and hypertensive (n = 15) primigravidae, and their mothers. There was no significant difference between the neonatal umbilical venous platelet cytosolic calcium concentration (p[Ca2+]i) in babies born to normotensive primigravidae or to those whose pregnancies were complicated by gestational hypertension (88 x 9 (SE) 2 x 5) in normotensive primagravidae, 80 x 6 (2 x 8) in pregnancy induced hypertension without proteinuria, and 89 x 3 (3 x 2) nmol/l in pre-eclampsia. There was also no significant difference in the p[Ca2+]i from the umbilical veins of the pregnancies studied and those of non-pregnant female volunteers in the follicular phase of their menstrual cycle. This was despite a gradual and significant rise in p[Ca2+]i with increasing severity of disease in the mothers of the babies studied (119 x 9 (4 x 1) in normotensive primagravidae, 130 x 8 (7 x 3) in pregnancy induced hypertension without proteinuria, and 148 x 2 (4 x 5 ) nmol/l in pre-eclampsia). The mean maternal p[Ca2+]i in the three samples returned to concentrations comparable with those in non-pregnant subjects by 12 weeks after birth. These data demonstrate no significant difference between the mean p[Ca2+]i in non-pregnant women and those obtained from the umbilical venous blood of normotensive or hypertensive primigravidae. They suggest that the functional hypoactivity of neonatal platelets is probably not secondary to a decrease in basal p[Ca2+]i. They also suggest that the progressively raised p[Ca2+]i in normal and hypertensive pregnancies might be due to a pregnancy specific factor that does not cross the placenta |
| تدمد: | 1468-2052 1359-2998 |
| DOI: | 10.1136/fn.71.1.f6 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14971e9b68023a4b7bdb77ed1af8bc80 https://doi.org/10.1136/fn.71.1.f6 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....14971e9b68023a4b7bdb77ed1af8bc80 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14682052 13592998 |
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| DOI: | 10.1136/fn.71.1.f6 |