Actigraph-Measured Movement Correlates of Attention-Deficit/Hyperactivity Disorder (ADHD) Symptoms in Young People with Tuberous Sclerosis Complex (TSC) with and without Intellectual Disability and Autism Spectrum Disorder (ASD)
| العنوان: | Actigraph-Measured Movement Correlates of Attention-Deficit/Hyperactivity Disorder (ADHD) Symptoms in Young People with Tuberous Sclerosis Complex (TSC) with and without Intellectual Disability and Autism Spectrum Disorder (ASD) |
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| المؤلفون: | Elizabeth Shephard, Charlotte Tye, Emma Woodhouse, Tom Earnest, Patrick Bolton, Holan Liang, Fintan Sheerin, Fiona McEwen |
| المصدر: | Brain Sciences, Vol 10, Iss 491, p 491 (2020) Brain Sciences; Volume 10; Issue 8; Pages: 491 Brain Sciences |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | tuberous sclerosis (TSC), attention-deficit/hyperactivity disorder (ADHD), activity levels, actigraphy, autism spectrum disorder (ASD), intellectual disability, epilepsy, Article, lcsh:RC321-571, 03 medical and health sciences, Tuberous sclerosis, Epilepsy, 0302 clinical medicine, Intellectual disability, mental disorders, medicine, Attention deficit hyperactivity disorder, 0501 psychology and cognitive sciences, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, business.industry, General Neuroscience, 05 social sciences, Genetic disorder, Actigraphy, medicine.disease, Cognitive test, Autism spectrum disorder, business, 030217 neurology & neurosurgery, 050104 developmental & child psychology, Clinical psychology |
| الوصف: | Actigraphy, an objective measure of motor activity, reliably indexes increased movement levels in attention-deficit/hyperactivity disorder (ADHD) and may be useful for diagnosis and treatment-monitoring. However, actigraphy has not been examined in complex neurodevelopmental conditions. This study used actigraphy to objectively measure movement levels in individuals with a complex neurodevelopmental genetic disorder, tuberous sclerosis (TSC). Thirty participants with TSC (11–21 years, 20 females, IQ = 35–108) underwent brief (approximately 1 h) daytime actigraph assessment during two settings: movie viewing and cognitive testing. Multiple linear regressions were used to test associations between movement measurements and parent-rated ADHD symptoms. Correlations were used to examine associations between actigraph measures and parent-rated ADHD symptoms and other characteristics of TSC (symptoms of autism spectrum disorder (ASD), intellectual ability (IQ), epilepsy severity, cortical tuber count). Higher movement levels during movies were associated with higher parent-rated ADHD symptoms. Higher ADHD symptoms and actigraph-measured movement levels during movies were positively associated with ASD symptoms and negatively associated with IQ. Inter-individual variability of movement during movies was not associated with parent-rated hyperactivity or IQ but was negatively associated with ASD symptoms. There were no associations with tuber count or epilepsy. Our findings suggest that actigraph-measured movement provides a useful correlate of ADHD in TSC. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-3425 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14926cbfd0c48327d34eb0b22cfd5e07 https://www.mdpi.com/2076-3425/10/8/491 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....14926cbfd0c48327d34eb0b22cfd5e07 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763425 |
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