Harnessing PTEN’s Growth Potential in Neuronal Development and Disease
| العنوان: | Harnessing PTEN’s Growth Potential in Neuronal Development and Disease |
|---|---|
| المؤلفون: | George Leondaritis, Britta J. Eickholt, Joachim Fuchs |
| المصدر: | Neuroscience Insights, Vol 15 (2020) Neuroscience Insights |
| بيانات النشر: | SAGE Publishing, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Nervous system, Plasticity related genes, Male, PTEN, LPPR3, Regulator, Disease, Biology, axonal growth, lcsh:RC321-571, 03 medical and health sciences, chemistry.chemical_compound, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Phosphatidylinositol Phosphates, Chlorocebus aethiops, medicine, Animals, Humans, development, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, PI3K/AKT/mTOR pathway, lipid phosphate phosphatase related, PRG2, Phosphatidylinositol (3,4,5)-trisphosphate, General Neuroscience, Axon extension, PTEN Phosphohydrolase, Membrane Proteins, Transmembrane protein, Axons, Phosphatidylinositol 3,4,5-trisphosphate, 030104 developmental biology, medicine.anatomical_structure, chemistry, nervous system, COS Cells, biology.protein, Commentary, Female, axonal branches, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | PTEN is a powerful regulator of neuronal growth. It globally suppresses axon extension and branching during both nervous system development and regeneration, by antagonizing growth-promoting PI3K/PI(3,4,5)P3 signaling. We recently identified that the transmembrane protein PRG2/LPPR3 functions as a modulator of PTEN function during axon morphogenesis. Our work demonstrates that through inhibition of PTEN activity, PRG2 stabilizes membrane PI(3,4,5)P3. In turn, PRG2 deficiency attenuates the formation of branches in a PTEN-dependent manner, albeit without affecting the overall growth capacity of extending axons. Thus, PRG2 is poised to temporally and locally relieve growth suppression mediated by PTEN in neurons and, in effect, to redirect growth specifically to axonal branches. In this commentary, we discuss potential implications and unresolved questions regarding the regulation of axonal PTEN in neurons. Given their widespread implication during neuronal development and regeneration, identification of mechanisms that confer spatiotemporal control of PTEN may unveil new approaches to reprogram PI3K signaling in neurodevelopmental disorders and regeneration research. |
| اللغة: | English |
| تدمد: | 2633-1055 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1469a22ed9d87149d008da89f1d4a2fa https://doaj.org/article/8485627ba22e4bd2898071d1f6c1ba8e |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1469a22ed9d87149d008da89f1d4a2fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26331055 |
|---|