Expert Consensus on the Management of Adverse Events from EGFR Tyrosine Kinase Inhibitors in the UK
| العنوان: | Expert Consensus on the Management of Adverse Events from EGFR Tyrosine Kinase Inhibitors in the UK |
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| المؤلفون: | Adam C.G. Thomas, D Fitzgerald, Catherine A. Harwood, Jason F. Lester, C Mulatero, S Subramanian, Nick Thatcher, Marianne Nicolson, S Compton, J. McPhelim, Raffaele Califano, Noor-ul-Ain Tariq, Rohit Lal |
| المصدر: | Drugs |
| بيانات النشر: | Springer International Publishing, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | medicine.medical_specialty, Consensus, Lung Neoplasms, Gastrointestinal Diseases, Afatinib, Antineoplastic Agents, Review Article, Skin Diseases, Gefitinib, Pharmacotherapy, Risk Factors, Internal medicine, Carcinoma, Non-Small-Cell Lung, Mucositis, medicine, Humans, Pharmacology (medical), Molecular Targeted Therapy, Lung cancer, Adverse effect, Protein Kinase Inhibitors, Dose-Response Relationship, Drug, business.industry, medicine.disease, Rash, United Kingdom, Surgery, respiratory tract diseases, ErbB Receptors, Treatment Outcome, Mutation, Quality of Life, Erlotinib, medicine.symptom, business, medicine.drug, Signal Transduction |
| الوصف: | Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) such as gefitinib, erlotinib, and afatinib are standard-of-care for first-line treatment of EGFR-mutant advanced non-small cell lung cancer (NSCLC). These drugs have a proven benefit in terms of higher response rate, delaying progression and improvement of quality of life over palliative platinum-based chemotherapy. The most common adverse events (AEs) are gastrointestinal (GI) (diarrhoea and stomatitis/mucositis) and cutaneous (rash, dry skin and paronychia). These are usually mild, but if they become moderate or severe, they can have a negative impact on the patient’s quality of life (QOL) and lead to dose modifications or drug discontinuation. Appropriate management of AEs, including prophylactic measures, supportive medications, treatment delays and dose reductions, is essential. A consensus meeting of a UK-based multidisciplinary panel composed of medical and clinical oncologists with a special interest in lung cancer, dermatologists, gastroenterologists, lung cancer nurse specialists and oncology pharmacists was held to develop guidelines on prevention and management of cutaneous (rash, dry skin and paronychia) and GI (diarrhoea, stomatitis and mucositis) AEs associated with the administration of EGFR-TKIs. These guidelines detail supportive measures, treatment delays and dose reductions for EGFR-TKIs. Although the focus of the guidelines is to support healthcare professionals in UK clinical practice, it is anticipated that the management strategies proposed will also be applicable in non-UK settings. |
| اللغة: | English |
| تدمد: | 1179-1950 0012-6667 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1460397732be4323de9c24bf4f4d1970 http://europepmc.org/articles/PMC4532717 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1460397732be4323de9c24bf4f4d1970 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11791950 00126667 |
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