Exercise activates the hypothalamic S1PR1–STAT3 axis through the central action of interleukin 6 in mice
| العنوان: | Exercise activates the hypothalamic S1PR1–STAT3 axis through the central action of interleukin 6 in mice |
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| المؤلفون: | Eduardo R. Ropelle, Leandro Pereira de Moura, Licio A. Velloso, Jose Carlos de Lima-Junior, Luciene Lenhare, Dennys E. Cintra, Thayana O. Micheletti, Mario J.A. Saad, Adelino Sanchez Ramos da Silva, Juliana A. Camargo, Gabriela R. Passos, Rodrigo S. Gaspar, Vagner R. R. Silva, Carlos K. Katashima, Alexandre Moura-Assis, Joseane Morari, José Rodrigo Pauli |
| المصدر: | Journal of Cellular Physiology. 233:9426-9436 |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, STAT3 Transcription Factor, 0301 basic medicine, medicine.medical_specialty, Physiology, Clinical Biochemistry, Hypothalamus, Mice, Obese, Physical exercise, Energy homeostasis, 03 medical and health sciences, 0302 clinical medicine, Physical Conditioning, Animal, Internal medicine, medicine, Animals, Humans, RNA, Messenger, STAT3, Receptor, Interleukin 6, Sphingosine-1-Phosphate Receptors, S1PR1, Injections, Intraventricular, biology, Interleukin-6, Cell Biology, Mice, Inbred C57BL, Receptors, Lysosphingolipid, 030104 developmental biology, Endocrinology, Knockout mouse, biology.protein, 030217 neurology & neurosurgery, Signal Transduction |
| الوصف: | Hypothalamic sphingosine-1-phosphate receptor 1 (S1PR1), the G protein-coupled receptor 1 of sphingosine-1-phosphate, has been described as a modulator in the control of energy homeostasis in rodents. However, this mechanism is still unclear. Here, we evaluate the role of interleukin 6 (IL-6) associated with acute physical exercise in the control of the hypothalamic S1PR1-signal transducer and activator of transcription 3 (STAT3) axis. Acute exercise session and an intracerebroventricular IL-6 injection increased S1PR1 protein content and STAT3 phosphorylation in the hypothalamus of lean and obese mice accompanied by a reduction in food consumption. Transcriptome analysis indicated a strong positive correlation between Il-6 and S1pr1 messenger RNA in several tissues of genetically diverse BXD mice strains and humans, including in the hypothalamus. Interestingly, exercise failed to stimulate the S1PR1-STAT3 axis in IL-6 knockout mice and the disruption of hypothalamic-specific IL-6 action blocked the anorexigenic effects of exercise. Taken together, our results indicate that physical exercise modulates the S1PR1 protein content in the hypothalamus, through the central action of IL-6. |
| تدمد: | 1097-4652 0021-9541 |
| DOI: | 10.1002/jcp.26818 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1391d335f2be5ad83a8cbf0501f21b77 https://doi.org/10.1002/jcp.26818 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1391d335f2be5ad83a8cbf0501f21b77 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974652 00219541 |
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| DOI: | 10.1002/jcp.26818 |