Leisure Activity, Brain β‐amyloid, and Episodic Memory in Adults with Down Syndrome
| العنوان: | Leisure Activity, Brain β‐amyloid, and Episodic Memory in Adults with Down Syndrome |
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| المؤلفون: | Patrick J. Lao, Ozioma C. Okonkwo, Bradley T. Christian, William E. Klunk, Karly Alex Cody, Sigan L. Hartley, Benjamin L. Handen, Annie Cohen, Iulia Mihaila, Dana L. Tudorascu |
| المصدر: | Developmental Neurobiology. 79:738-749 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Down syndrome, Memory, Episodic, Leisure activity, Disease, Neuropathology, Biology, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, Leisure Activities, 0302 clinical medicine, Developmental Neuroscience, β amyloid, Surveys and Questionnaires, medicine, Humans, Longitudinal Studies, Baseline (configuration management), Association (psychology), Episodic memory, Amyloid beta-Peptides, Brain, Middle Aged, medicine.disease, 030104 developmental biology, Positron-Emission Tomography, Female, Down Syndrome, 030217 neurology & neurosurgery, Follow-Up Studies, Clinical psychology |
| الوصف: | The present study provided an investigation of associations between leisure activity and early Alzheimer's disease neuropathology (i.e., brain β-amyloid) and episodic memory in a sample of 65 adults with Down syndrome (aged 30-53 years), at baseline and follow-up, approximately three years apart. Findings indicated that leisure activity at baseline was not associated with brain β-amyloid at baseline or change in brain β-amyloid from baseline to follow-up. Greater cognitively stimulating leisure activity at baseline was associated with better episodic memory at baseline, and greater social leisure activity at baseline was associated with less decline in episodic memory from baseline to follow-up. High (as opposed to low) levels of social and overall leisure activity at baseline moderated the association between increase in brain β-amyloid and decline in episodic memory, from baseline to follow-up. Findings suggest that cognitively stimulating and social leisure activity could protect against the effect of Alzheimer's disease neuropathology on episodic memory in adults with Down syndrome. |
| تدمد: | 1932-846X 1932-8451 |
| DOI: | 10.1002/dneu.22677 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fd1ce5b35947140865e3fa177acd1c https://doi.org/10.1002/dneu.22677 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....12fd1ce5b35947140865e3fa177acd1c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1932846X 19328451 |
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| DOI: | 10.1002/dneu.22677 |