An Enantioselective Synthesis of Differentially Protected erythro-α,β-Diamino Acids and Its Application to the Synthesis of an Analogue of Rhodopeptin B5
| العنوان: | An Enantioselective Synthesis of Differentially Protected erythro-α,β-Diamino Acids and Its Application to the Synthesis of an Analogue of Rhodopeptin B5 |
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| المؤلفون: | Timothy B. Durham, Marvin J. Miller |
| المصدر: | The Journal of Organic Chemistry. 68:35-42 |
| بيانات النشر: | American Chemical Society (ACS), 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Antifungal, chemistry.chemical_classification, Antifungal Agents, Magnetic Resonance Spectroscopy, Molecular Structure, medicine.drug_class, Stereochemistry, Organic Chemistry, Rhodopeptin B5, Enantioselective synthesis, Diastereomer, Stereoisomerism, General Medicine, beta-Lactams, Peptides, Cyclic, Chemical synthesis, Cyclic peptide, chemistry.chemical_compound, chemistry, Diamine, medicine, Lactam, Combinatorial Chemistry Techniques, Azide, Amino Acids |
| الوصف: | Methodology for the enantioselective synthesis of differentially protected erythro-alpha,beta-diamino acids from N-tosyloxy beta-lactams is reported. The requisite N-tosyloxy beta-lactams are readily available from simple beta-keto esters. The reported approach is flexible and compatible with a variety of functional groups. The synthetic utility of the method is demonstrated through its application to the preparation of an analogue of the antifungal cyclic peptide rhodopeptin B5. |
| تدمد: | 1520-6904 0022-3263 |
| DOI: | 10.1021/jo016276m |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c4f16b87d27cc030697b4ba332e6e0 https://doi.org/10.1021/jo016276m |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....12c4f16b87d27cc030697b4ba332e6e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206904 00223263 |
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| DOI: | 10.1021/jo016276m |