Wilms Tumor Gene Product

التفاصيل البيبلوغرافية
العنوان: Wilms Tumor Gene Product
المؤلفون: Louise Quenneville, Harry Hwang, Allen M. Gown, Hadi Yaziji
المصدر: Applied Immunohistochemistry & Molecular Morphology. :122-126
بيانات النشر: Ovid Technologies (Wolters Kluwer Health), 2004.
سنة النشر: 2004
مصطلحات موضوعية: Ovarian Neoplasms, endocrine system, Histology, endocrine system diseases, Breast Neoplasms, Wilms' tumor, Biology, medicine.disease, Adenocarcinoma, Mucinous, Immunohistochemistry, Sensitivity and Specificity, female genital diseases and pregnancy complications, Cystadenocarcinoma, Serous, Pathology and Forensic Medicine, Diagnosis, Differential, Gene product, Medical Laboratory Technology, Serous fluid, Antigens, Neoplasm, medicine, Cancer research, Humans, Female, WT1 Proteins
الوصف: Carcinomas of ovarian surface epithelial origin can arise from, and often present at, extraovarian sites. There are few available markers for the positive identification of carcinomas of ovarian surface epithelial origin, which might aid in distinguishing them from metastatic carcinomas, such as of breast, colon, or lung origin. Recently, the Wilms tumor gene product (WT-1) has been shown to be expressed in ovarian surface and mesothelial epithelium. We tested the hypothesis that WT-1 would be a sensitive and specific marker of ovarian surface epithelium carcinomas. An archived series of 116 ovarian carcinomas (57 serous [43 ovarian, 14 extraovarian], 31 mucinous, 15 clear cell, 13 endometrioid), 118 breast carcinomas, 46 colonic carcinomas, and 45 nonsmall cell lung cancers were selected. A polyclonal antibody to the WT-1 gene product was applied to deparaffinized, formalin-fixed tissue sections after epitope retrieval. Fifty-two of 57 (93%) serous carcinomas of ovarian surface epithelial origin were WT-1-positive, in a nuclear pattern, with virtually all the tumor cell population positive in the majority of cases. None of the mucinous, clear cell, or endometrioid ovarian cancers were positive, and only 8 of 118 breast, 0 of 46 colonic, and 0 of 45 lung nonsmall cell carcinomas were WT-1-positive. These findings demonstrate that WT-1 is a highly sensitive and specific marker of serous carcinomas of ovarian surface epithelial origin (both ovarian and extraovarian). These results also contradict recent reports demonstrating WT-1 expression in both breast and lung carcinomas.
تدمد: 1541-2016
DOI: 10.1097/00129039-200406000-00004
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120d7365ebbe1275ee1b689aa164d52e
https://doi.org/10.1097/00129039-200406000-00004
رقم الانضمام: edsair.doi.dedup.....120d7365ebbe1275ee1b689aa164d52e
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15412016
DOI:10.1097/00129039-200406000-00004