First in man study of [18F]fluoro-PEG-folate PET: a novel macrophage imaging technique to visualize rheumatoid arthritis
| العنوان: | First in man study of [18F]fluoro-PEG-folate PET: a novel macrophage imaging technique to visualize rheumatoid arthritis |
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| المؤلفون: | Qingshou Chen, S. Pieplenbosch, Adriaan A. Lammertsma, Albert D. Windhorst, Gerrit Jansen, Conny J. van der Laken, N. J. F. Verweij, Alexandre E Voskuyl, Otto S. Hoekstra, Marieke M. ter Wee, Philip S. Low, Stefan T G Bruijnen, Maqsood Yaqub |
| المساهمون: | Rheumatology, Radiology and nuclear medicine, Epidemiology and Data Science, AII - Inflammatory diseases, ACS - Heart failure & arrhythmias, AMS - Tissue Function & Regeneration |
| المصدر: | Verweij, N J F, Yaqub, M, Bruijnen, S T G, Pieplenbosch, S, ter Wee, M M, Jansen, G, Chen, Q, Low, P S, Windhorst, A D, Lammertsma, A A, Hoekstra, O S, Voskuyl, A E & van der Laken, C J 2020, ' First in man study of [18F]fluoro-PEG-folate PET: a novel macrophage imaging technique to visualize rheumatoid arthritis ', Scientific Reports, vol. 10, no. 1, 1047 . https://doi.org/10.1038/s41598-020-57841-x Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports, 10(1):1047. Nature Publishing Group |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 030203 arthritis & rheumatology, 0301 basic medicine, Biodistribution, First-in-man study, Multidisciplinary, PEG-folate, Chemistry, lcsh:R, Arthritis, lcsh:Medicine, Pharmacology, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Folate receptor, Rheumatoid arthritis, medicine, Macrophage, lcsh:Q, Imaging Signal, lcsh:Science |
| الوصف: | Non-invasive imaging of arthritis activity in rheumatoid arthritis (RA) patients using macrophage PET holds promise for early diagnosis and therapeutic response monitoring. Previously obtained results with macrophage tracer (R)-[11C]PK11195 were encouraging, but the imaging signal could be further improved by reduction of background uptake. Recently, the novel macrophage tracer [18F]fluoro-PEG-folate was developed. This tracer showed excellent targeting of the folate receptor β on activated macrophages in synovial tissue in a preclinical arthritic rat model. We performed three substudies to investigate the biodistribution, potential for imaging arthritis and kinetic properties of [18F]fluoro-PEG-folate in RA patients. Firstly, biodistribution demonstrated fast clearance of [18F]fluoro-PEG-folate from heart and blood vessels and no dose limiting uptake in organs. Secondly, [18F]fluoro-PEG-folate showed uptake in arthritic joints with significantly lower background and hence significantly higher target-to-background ratios as compared to reference macrophage tracer (R)-[11C]PK11195. Lastly, dynamic scanning demonstrated fast tracer uptake in affected joints, reaching a plateau after 1 minute, co-existing with a rapid blood clearance. In conclusion, this first in man study demonstrates the potential of [18F]fluoro-PEG-folate to image arthritis activity in RA with favourable imaging characteristics of rapid clearance and low background uptake, that allow for detection of inflammatory activity in the whole body. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| DOI: | 10.1038/s41598-020-57841-x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a5bab9d670df6f44a14cb9e8e9013b https://research.vumc.nl/en/publications/c76703cf-a87a-47c4-bd60-f7cd9dbfeb94 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....11a5bab9d670df6f44a14cb9e8e9013b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-020-57841-x |