Early vascular ageing biomarkers in osteoporotic outpatients: a pilot study
| العنوان: | Early vascular ageing biomarkers in osteoporotic outpatients: a pilot study |
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| المؤلفون: | Anastasia Xourafa, Rosario Rapisarda, Luca Zanoli, Agostino Gaudio, Pietro Castellino, Salvatore Santo Signorelli, Antonino Catalano |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Osteoporosis, Population, lcsh:Medicine, 030204 cardiovascular system & hematology, Predictive markers, Carotid Intima-Media Thickness, Article, 03 medical and health sciences, 0302 clinical medicine, Absorptiometry, Photon, Internal medicine, Outpatients, medicine, Humans, 030212 general & internal medicine, cardiovascular diseases, education, Inverse correlation, lcsh:Science, Pulse wave velocity, Femoral neck, Aged, education.field_of_study, Multidisciplinary, business.industry, Femur Neck, lcsh:R, atherosclerosis, elderly, pulse wave velocity, arterial stiffness, postmenopause, bone mineral density, Hemodynamics, Endocrine system and metabolic diseases, Middle Aged, medicine.disease, Cardiovascular biology, Vascular ageing, medicine.anatomical_structure, Carotid-Femoral Pulse Wave Velocity, Arterial stiffness, cardiovascular system, Female, lcsh:Q, Densitometry, business, Biomarkers |
| الوصف: | Osteoporosis and atherosclerosis are significant public health problems that often coexist, especially in the elderly. Although some studies have reported an age-dependent relationship, others have suggested a causal relationship between osteoporosis and atherosclerosis. The aim of our study was to evaluate the cardiovascular risk in a population of patients with osteoporosis by measuring carotid intima-media thickness (cIMT) and carotid-femoral pulse wave velocity (cf-PWV). A total of 58 patients with osteoporosis and an equal number of healthy control subjects were enrolled. All subjects underwent (1) a bone densitometry examination using dual X-ray absorptiometry, (2) a vascular evaluation for the measurements of cIMT and cf-PWV and (3) a blood sample for the evaluation of lipids and phosphocalcic metabolism. Patients with osteoporosis had a significant increase in cIMT and cf-PWV. There was also a significant inverse correlation between the femoral neck BMD and cf-PWV values. In conclusion, osteoporotic outpatients have earlier vascular ageing, with an increase of arterial stiffness. These data support a possible association between osteoporosis and atherosclerosis independent of age. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| DOI: | 10.1038/s41598-020-76427-1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11892df5966985dbc56cddd4a0c03066 http://link.springer.com/article/10.1038/s41598-020-76427-1 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....11892df5966985dbc56cddd4a0c03066 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-020-76427-1 |