No high-risk HPV detected in SCC of the oral tongue in the absolute absence of tobacco and alcohol--a case study of seven patients
| العنوان: | No high-risk HPV detected in SCC of the oral tongue in the absolute absence of tobacco and alcohol--a case study of seven patients |
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| المؤلفون: | P. van Cleef, Willem J. G. Melchers, Matthias A.W. Merkx, Piet J. Slootweg, P.C.M. de Wilde, T. J. H. Siebers |
| المصدر: | Oral and Maxillofacial Surgery, 12, 4, pp. 185-8 Oral and Maxillofacial Surgery, 12, 185-8 |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Risk, medicine.medical_specialty, Pathology, Alcohol Drinking, Oral cavity, Invasive mycoses and compromised host [N4i 2], Young Adult, Tongue, Translational research [ONCOL 3], medicine, Humans, Basal cell, Head and neck, Papillomaviridae, Molecular diagnosis, prognosis and monitoring [UMCN 1.2], Human papilloma virus, Aged, 80 and over, business.industry, Smoking, Poverty-related infectious diseases [N4i 3], Middle Aged, Dermatology, Tongue Neoplasms, stomatognathic diseases, medicine.anatomical_structure, Otorhinolaryngology, High risk hpv, Evaluation of complex medical interventions [NCEBP 2], Oral and maxillofacial surgery, Carcinoma, Squamous Cell, Surgery, Female, Functional Imaging [UMCN 1.1], Microbial pathogenesis and host defense [UMCN 4.1], Oral Surgery, business, Mobile tongue, Infection and autoimmunity [NCMLS 1], Immunity, infection and tissue repair [NCMLS 1] |
| الوصف: | Contains fulltext : 71141.pdf (Publisher’s version ) (Closed access) INTRODUCTION: In recent years, there has been an increase in the number of patients with squamous cell carcinoma (SCC) of the mobile tongue in the absence of tobacco and alcohol. The literature suggests that human papilloma virus (HPV) may be involved in the development of SCC of the head and neck, especially in non-smoking and non-drinking patients. In the oral cavity, however, the presence of the HPV genome has been reported with various percentages. This may be due to misclassification of the oropharyngeal tongue as oral cavity subsite and the use of various detection methods. MATERIALS AND METHODS: Therefore, we evaluated the role of HPV in seven consecutive non-smoking and non-drinking patients (2003-2006) with a SCC located at the oral, mobile tongue using in situ hybridization and SPF(10)Line Blot 25 polymerase chain reaction assays. RESULTS: No HPV was detected in these specimens. To further determine whether a relationship exists between HPV and SCC in the absence of tobacco and alcohol, subsequent studies at specific locations are necessary. |
| وصف الملف: | application/pdf |
| تدمد: | 1865-1550 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1132bf4756ac4e0caecd0bb16970d58e https://pubmed.ncbi.nlm.nih.gov/18762997 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1132bf4756ac4e0caecd0bb16970d58e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18651550 |
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