Assessing prediction of diabetes in older adults using different adiposity measures: a 7 year prospective study in 6,923 older men and women
| العنوان: | Assessing prediction of diabetes in older adults using different adiposity measures: a 7 year prospective study in 6,923 older men and women |
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| المؤلفون: | Shah Ebrahim, Naveed Sattar, Olia Papacosta, Mary C Thomas, SG Wannamethee, Peter H. Whincup, Debbie A Lawlor, Claire Carson |
| المصدر: | Diabetologia |
| بيانات النشر: | Springer-Verlag, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Gerontology, Male, medicine.medical_specialty, Waist, Endocrinology, Diabetes and Metabolism, Population, Type 2 diabetes, Article, Body Mass Index, Waist–hip ratio, Sex Factors, Predictive Value of Tests, Internal Medicine, medicine, Humans, Prospective Studies, education, Prospective cohort study, Adiposity, Aged, education.field_of_study, business.industry, Waist-Hip Ratio, Waist-to-hip ratio, Incidence, nutritional and metabolic diseases, Abdominal adiposity, Middle Aged, medicine.disease, Obesity, Surgery, Diabetes Mellitus, Type 2, ROC Curve, Area Under Curve, Cohort, Waist circumference, Female, business, Body mass index |
| الوصف: | Aims/hypothesis The aim of this study was to examine whether waist circumference (WC) or WHR improve diabetes prediction beyond body mass index in older men and women, and to define optimal cut-off points. Methods In this prospective study, non-diabetic men (n = 3,519) and women (n = 3,404) aged 60–79 years were followed up for 7 years. There were 169 and 128 incident cases of type 2 diabetes in men and women, respectively. Results BMI, WC and WHR all showed strong associations with incident type 2 diabetes independent of potential confounders. In men, the adjusted relative risks (top vs lowest quartile) were 4.71 (95% CI 2.45–9.03) for BMI, 3.53 (95% CI 1.92–6.48) for WC and 2.76 (95% CI 1.58–4.82) for WHR. For women, the corresponding relative risks were 4.10 (95% CI 2.16–7.79), 12.18 (95% CI 4.83–30.74) and 5.61 (95% CI 2.84–11.09) for BMI, WC and WHR, respectively. Receiver-operating characteristic curve analysis revealed similar associations for BMI and WC in predicting diabetes in men (AUC = 0.726 and 0.713, respectively); WHR was the weakest predictor (AUC = 0.656). In women, WC was a significantly stronger predictor (AUC = 0.780) than either BMI (AUC = 0.733) or WHR (AUC = 0.728; p |
| اللغة: | English |
| تدمد: | 1432-0428 0012-186X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1050cad80b6d01ee2b975edb46f7420f http://europepmc.org/articles/PMC2850526 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1050cad80b6d01ee2b975edb46f7420f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
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