DIANA-miRGen v4: indexing promoters and regulators for more than 1500 microRNAs
| العنوان: | DIANA-miRGen v4: indexing promoters and regulators for more than 1500 microRNAs |
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| المؤلفون: | Nikos Perdikopanis, Ioannis Kavakiotis, Georgios Georgakilas, Dimitris Grigoriadis, Artemis G. Hatzigeorgiou, Vasileios Pierros, Panagiotis Alexiou |
| المصدر: | UnpayWall ORCID Microsoft Academic Graph PubMed Central Nucleic Acids Research |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cell type, Transcription, Genetic, AcademicSubjects/SCI00010, Primary Cell Culture, Computational biology, Biology, ENCODE, Cell Line, 03 medical and health sciences, 0302 clinical medicine, microRNA, Genetics, Humans, Database Issue, Promoter Regions, Genetic, 030304 developmental biology, computer.programming_language, Internet, 0303 health sciences, Genome, Base Sequence, Fantom, Molecular Sequence Annotation, Promoter, Cap analysis gene expression, DNA binding site, MicroRNAs, Cell culture, 030220 oncology & carcinogenesis, Transcription Initiation Site, Databases, Nucleic Acid, computer, Software, Protein Binding, Transcription Factors |
| الوصف: | Deregulation of microRNA (miRNA) expression plays a critical role in the transition from a physiological to a pathological state. The accurate miRNA promoter identification in multiple cell types is a fundamental endeavor towards understanding and characterizing the underlying mechanisms of both physiological as well as pathological conditions. DIANA-miRGen v4 (www.microrna.gr/mirgenv4) provides cell type specific miRNA transcription start sites (TSSs) for over 1500 miRNAs retrieved from the analysis of >1000 cap analysis of gene expression (CAGE) samples corresponding to 133 tissues, cell lines and primary cells available in FANTOM repository. MiRNA TSS locations were associated with transcription factor binding site (TFBSs) annotation, for >280 TFs, derived from analyzing the majority of ENCODE ChIP-Seq datasets. For the first time, clusters of cell types having common miRNA TSSs are characterized and provided through a user friendly interface with multiple layers of customization. DIANA-miRGen v4 significantly improves our understanding of miRNA biogenesis regulation at the transcriptional level by providing a unique integration of high-quality annotations for hundreds of cell specific miRNA promoters with experimentally derived TFBSs. |
| تدمد: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/gkaa1060 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100a0472f4245d411f7884aa80487720 https://doi.org/10.1093/nar/gkaa1060 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....100a0472f4245d411f7884aa80487720 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13624962 03051048 |
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| DOI: | 10.1093/nar/gkaa1060 |