Selective Regulation of 5-HT1B Serotonin Receptor Expression in the Striatum by Dopamine Depletion and Repeated L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias
| العنوان: | Selective Regulation of 5-HT1B Serotonin Receptor Expression in the Striatum by Dopamine Depletion and Repeated L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias |
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| المؤلفون: | Anthony R. West, Fernando E. Padovan-Neto, Feras Altwal, Nivea M. F. Voelkner, Joel A. Beverley, Heinz Steiner, Santanna Patterson |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Dyskinesia, Drug-Induced, medicine.medical_specialty, Tyrosine 3-Monooxygenase, Dopamine, Receptor expression, Neuroscience (miscellaneous), Dynorphin, Striatum, Dynorphins, Article, Levodopa, Rats, Sprague-Dawley, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Internal medicine, Basal ganglia, medicine, Animals, NEUROLOGIA, Receptor, 5-HT receptor, Behavior, Animal, Chemistry, Enkephalins, Corpus Striatum, 030104 developmental biology, Endocrinology, Gene Expression Regulation, nervous system, Neurology, Receptor, Serotonin, 5-HT1B, Serotonin, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Dopamine and serotonin in the basal ganglia interact in a bidirectional manner. On the one hand, serotonin (5-HT) receptors regulate the effects of dopamine agonists on several levels, ranging from molecular signaling to behavior. These interactions include 5-HT receptor-mediated facilitation of dopamine receptor-induced gene regulation in striatal output pathways, which involves the 5-HT1B receptor and others. Conversely, there is evidence that dopamine action by psychostimulants regulates 5-HT1B receptor expression in the striatum. To further investigate the effects of dopamine and agonists on 5-HT receptors, we assessed the expression of 5-HT1B and other serotonin receptor subtypes in the striatum after unilateral dopamine depletion by 6-OHDA and subsequent treatment with L-DOPA (5 mg/kg; 4 weeks). Neither dopamine depletion nor L-DOPA treatment produced significant changes in 5-HT2C, 5-HT4, or 5-HT6 receptor expression in the striatum. In contrast, the 6-OHDA lesion caused a (modest) increase in 5-HT1B mRNA levels throughout the striatum. Moreover, repeated L-DOPA treatment markedly further elevated 5-HT1B expression in the dopamine-depleted striatum, an effect that was most robust in the sensorimotor striatum. A minor L-DOPA-induced increase in 5-HT1B expression was also seen in the intact striatum. These changes in 5-HT1B expression mimicked changes in the expression of neuropeptide markers (dynorphin, enkephalin mRNA) in striatal projection neurons. After repeated L-DOPA treatment, the severity of L-DOPA-induced dyskinesias and turning behavior was positively correlated with the increase in 5-HT1B expression in the associative, but not sensorimotor, striatum ipsilateral to the lesion, suggesting that associative striatal 5-HT1B receptors may play a role in L-DOPA-induced behavioral abnormalities. |
| تدمد: | 1559-1182 0893-7648 |
| DOI: | 10.1007/s12035-019-01739-x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8c9b55edb2cfb734766b33b6cce1aa https://doi.org/10.1007/s12035-019-01739-x |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0f8c9b55edb2cfb734766b33b6cce1aa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15591182 08937648 |
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| DOI: | 10.1007/s12035-019-01739-x |