PD-L1 Inhibitors: Different Classes, Activities, and Mechanisms of Action
العنوان: | PD-L1 Inhibitors: Different Classes, Activities, and Mechanisms of Action |
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المؤلفون: | Lukasz Skalniak, Radoslaw Kitel, Jacek Plewka, Tad A. Holak, Bogdan Musielak, Damian Muszak, Ewa Surmiak, Justyna Kocik-Krol, Katarzyna Magiera-Mularz |
المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 11797, p 11797 (2021) International Journal of Molecular Sciences |
سنة النشر: | 2021 |
مصطلحات موضوعية: | Peptidomimetic, QH301-705.5, medicine.medical_treatment, Computational biology, CHO Cells, Catalysis, B7-H1 Antigen, Inorganic Chemistry, Jurkat Cells, Cricetulus, Cancer immunotherapy, PD-L1, medicine, Animals, Humans, Physical and Theoretical Chemistry, Biology (General), Molecular Biology, PD-L1 inhibitor, QD1-999, Immune Checkpoint Inhibitors, Spectroscopy, biology, Chemistry, Communication, Organic Chemistry, General Medicine, Immunotherapy, immune checkpoint blockade, Ligand (biochemistry), Immune checkpoint, In vitro, Computer Science Applications, biology.protein, Drug Evaluation, immunotherapy, Peptidomimetics |
الوصف: | Targeting the programmed cell death protein 1/programmed cell death 1 ligand 1 (PD-1/PD-L1) interaction has become an established strategy for cancer immunotherapy. Although hundreds of small-molecule, peptide, and peptidomimetic inhibitors have been proposed in recent years, only a limited number of drug candidates show good PD-1/PD-L1 blocking activity in cell-based assays. In this article, we compare representative molecules from different classes in terms of their PD-1/PD-L1 dissociation capacity measured by HTRF and in vitro bioactivity determined by the immune checkpoint blockade (ICB) co-culture assay. We point to recent discoveries that underscore important differences in the mechanisms of action of these molecules and also indicate one principal feature that needs to be considered, which is the eventual human PD-L1 specificity. |
تدمد: | 1422-0067 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f846fc8bfbfa8eca4fdf24197328b1f https://pubmed.ncbi.nlm.nih.gov/34769226 |
Rights: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....0f846fc8bfbfa8eca4fdf24197328b1f |
قاعدة البيانات: | OpenAIRE |
تدمد: | 14220067 |
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