Statin effect on thrombin inhibitor effectiveness during percutaneous coronary intervention: a post-hoc analysis from the ISAR-REACT 3 trial
| العنوان: | Statin effect on thrombin inhibitor effectiveness during percutaneous coronary intervention: a post-hoc analysis from the ISAR-REACT 3 trial |
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| المؤلفون: | Gert Richardt, Melchior Seyfarth, Josef Dirschinger, Peter B. Berger, Ahmed A. Khattab, Gjin Ndrepepa, Heinz Joachim Büttner, Stefanie Schulz, Albert Schömig, Jürgen Pache, Julinda Mehilli, Franz-Josef Neumann, Adnan Kastrati |
| المصدر: | Khattab, Ahmed Aziz; Ndrepepa, Gjin; Schulz, Stefanie; Neumann, Franz-Josef; Mehilli, Julinda; Büttner, Heinz Joachim; Pache, Jürgen; Seyfarth, Melchior; Dirschinger, Josef; Kastrati, Adnan; Berger, Peter B.; Schömig, Albert; Richardt, Gert (2011). Statin effect on thrombin inhibitor effectiveness during percutaneous coronary intervention: a post-hoc analysis from the ISAR-REACT 3 trial. Clinical research in cardiology, 100(7), pp. 579-585. Springer-Verlag 10.1007/s00392-011-0282-7 <http://dx.doi.org/10.1007/s00392-011-0282-7> |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Statin, medicine.drug_class, medicine.medical_treatment, 610 Medicine & health, Coronary Artery Disease, Antithrombins, Coronary artery disease, Internal medicine, Antithrombotic, Post-hoc analysis, Humans, Medicine, Bivalirudin, Drug Interactions, cardiovascular diseases, Myocardial infarction, Angioplasty, Balloon, Coronary, Aged, Heparin, business.industry, Percutaneous coronary intervention, General Medicine, Hirudins, Middle Aged, medicine.disease, Peptide Fragments, Recombinant Proteins, Treatment Outcome, Conventional PCI, Cardiology, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cardiology and Cardiovascular Medicine, business, medicine.drug |
| الوصف: | Objective: To determine whether statin therapy influences the efficacy of thrombin inhibitor bivalirudin or unfractionated heparin (UFH) during PCI. Setting and patients: The post-hoc analysis of the ISAR-REACT 3 Trial included 4,570 patients: 3,106 patients were on statin therapy and 1,464 patients were not on statin therapy at the time of PCI procedure. Main outcome measures: The primary outcome of this analysis was the 30-day composite of death, myocardial infarction, target vessel revascularization (TVR) or major bleeding. Results: The primary outcome occurred in 7.9% patients (n=246) in the statin group versus 9.8% (n=143) in the non-statin group (P=0.036). There was an interaction in univariate (P=0.028) and multivariable (P=0.026) analysis between pre-PCI statin therapy and the type of antithrombotic therapy regarding myocardial infarction. In the statin group, bivalirudin significantly reduced the incidence of major bleeding (2.6 vs. 4.3%, P=0.013) with no significant difference in the incidence of myocardial infarction (4.9 vs. 5.2%; P=0.73) compared with UFH. In the non-statin group, bivalirudin was inferior to UFH regarding the incidence of myocardial infarction (7.1 vs. 4.1%, P=0.013), yet major bleeding remained lower among bivalirudin-treated patients (4.0 vs. 5.2%, P=0.25). Conclusion: This post-hoc analysis suggests the existence of an interaction between statin therapy before PCI and antithrombotic therapy during PCI. Patients receiving bivalirudin therapy at the time of PCI showed less periprocedural myocardial infarction when on pre-PCI statin therapy which has to be investigated in further studies |
| وصف الملف: | application/pdf |
| تدمد: | 1861-0692 1861-0684 |
| DOI: | 10.1007/s00392-011-0282-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f82f57942cb48e3649754702cac59b9 https://doi.org/10.1007/s00392-011-0282-7 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0f82f57942cb48e3649754702cac59b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18610692 18610684 |
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| DOI: | 10.1007/s00392-011-0282-7 |