Alcohol Consumption Mediates the Relationship Between ADH1B and DSM-IV Alcohol Use Disorder and Criteria
| العنوان: | Alcohol Consumption Mediates the Relationship Between ADH1B and DSM-IV Alcohol Use Disorder and Criteria |
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| المؤلفون: | Howard J. Edenberg, Amos Frisch, Jacquelyn L. Meyers, Efrat Aharonovich, Abraham Weizman, Eliana Greenstein, Joel Gelernter, Bari Kilcoyne, Dvora Shmulewitz, Deborah S. Hasin, Baruch Spivak |
| المصدر: | Scopus-Elsevier |
| بيانات النشر: | Alcohol Research Documentation, Inc., 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Health (social science), Alcohol Drinking, Genotype, Poison control, Alcohol, Alcohol use disorder, Toxicology, Logistic regression, Lower risk, Polymorphism, Single Nucleotide, Young Adult, chemistry.chemical_compound, mental disorders, medicine, Humans, Israel, Psychiatry, Allele frequency, Alcohol dehydrogenase, biology, business.industry, Alcohol Dehydrogenase, ADH1B, Middle Aged, medicine.disease, Psychiatry and Mental health, Logistic Models, chemistry, biology.protein, Female, business, Alcohol-Related Disorders, Research Article |
| الوصف: | A single nucleotide variation in the alcohol dehydrogenase 1B (ADH1B) gene, rs1229984, produces an ADH1B enzyme with faster acetaldehyde production. This protective variant is associated with lower alcohol consumption and lower risk for alcohol use disorders (AUDs). Based on the premise that faster ADH1B kinetics decreases alcohol consumption, we formally tested if the association between ADH1B variant rs1229984 and AUDs occurs through consumption. We also tested whether the association between rs1229984 and each of the 11 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), AUD criteria occurs through consumption.A total of 1,130 lifetime drinkers from an Israeli household sample were assessed with a structured interview and genotyped for rs1229984 (protective allele frequency = 0.28). Logistic regression evaluated the association between rs1229984 and each phenotype (AUDs, 11 individual DSM-IV criteria). For phenotypes significantly related to rs1229984, the effect through consumption was tested with logistic regression and bootstrapping.ADH1B rs1229984 was significantly associated with AUDs and six criteria, with odds ratios ranging from 1.32 to 1.96. The effect through consumption was significant for these relationships, explaining 23%-74% of the total ADH1B effect.This is the first study to show that ADH1B rs1229984 is related to 6 of the 11 DSM-IV AUD criteria and that alcohol consumption explained a significant proportion of these associations and the association of ADH1B with AUDs. Better understanding of the relationship between ADH1B and the DSM-IV AUD criteria, including effects through consumption, will enhance our understanding of the etiologic model through which AUDs can occur. |
| تدمد: | 1938-4114 1937-1888 |
| DOI: | 10.15288/jsad.2014.75.635 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e815243d29699d5ff92e7f2985202a1 https://doi.org/10.15288/jsad.2014.75.635 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0e815243d29699d5ff92e7f2985202a1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19384114 19371888 |
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| DOI: | 10.15288/jsad.2014.75.635 |