Serum urate and cardiovascular events in the DCCT/EDIC study
| العنوان: | Serum urate and cardiovascular events in the DCCT/EDIC study |
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| المؤلفون: | Amisha Wallia, Samuel Dagogo-Jack, Ionut Bebu, Trevor J. Orchard, Barbara H. Braffett, Timothy J. Lyons, Alicia J. Jenkins, Arpita Basu, W. Timothy Garvey, Maria F. Lopes-Virella, John M. Lachin |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Science, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, Endocrinology, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Epidemiology, medicine, Humans, Hyperuricemia, cardiovascular diseases, Metabolic Syndrome, Type 1 diabetes, Multidisciplinary, business.industry, Middle Aged, medicine.disease, Uric Acid, Diabetes Mellitus, Type 1, Risk factors, Cardiovascular Diseases, Heart Disease Risk Factors, Cohort, Medicine, Female, Metabolic syndrome, business, Mace |
| الوصف: | In type 2 diabetes, hyperuricemia is associated with cardiovascular disease (CVD) and the metabolic syndrome (MetS), but associations in type 1 diabetes (T1D) have not been well-defined. This study examined the relationships between serum urate (SU) concentrations, clinical and biochemical factors, and subsequent cardiovascular events in a well-characterized cohort of adults with T1D. In 973 participants with T1D in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC), associations were defined between SU, measured once in blood collected 1997–2000, and (a) concurrent MetS and (b) incident ‘any CVD’ and major adverse cardiovascular events (MACE) through 2013. SU was higher in men than women [mean (SD): 4.47 (0.99) vs. 3.39 (0.97) mg/dl, respectively, p Trial registration clinicaltrials.gov NCT00360815 and NCT00360893. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db6a0485c835ecd5ee1065359316a30 https://doaj.org/article/f9fee4388877495b97606fb3d560869c |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0db6a0485c835ecd5ee1065359316a30 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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