The effects of morphine and halothane anaesthesia on urine norepinephrine during surgery for congenital heart disease
| العنوان: | The effects of morphine and halothane anaesthesia on urine norepinephrine during surgery for congenital heart disease |
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| المؤلفون: | Wen-Shin Liu, Theodore H. Stanley, George D. Lathrop |
| المصدر: | Canadian Anaesthetists’ Society Journal. 23:58-70 |
| بيانات النشر: | Springer Science and Business Media LLC, 1976. |
| سنة النشر: | 1976 |
| مصطلحات موضوعية: | Heart Defects, Congenital, Male, medicine.medical_specialty, Time Factors, Heart disease, Blood Pressure, Urine, Heart Septal Defects, Atrial, Norepinephrine (medication), Excretion, Norepinephrine, Catecholamines, Respiration, medicine, Humans, Child, Tetralogy of Fallot, Dose-Response Relationship, Drug, Morphine, business.industry, General Medicine, medicine.disease, Surgery, Anesthesiology and Pain Medicine, Anesthesia, Anesthesia, Intravenous, Female, Halothane, Anesthesia, Inhalation, business, medicine.drug |
| الوصف: | Urine excretion rates of norepinephrine were measured in 15 children with Tetralogy of Fallot and 25 with atrial septal secundum defects anaesthetized with halothane or morphine before, during and for two hours after surgical correction of their cardiac defects. All patients were paralyzed with d-tubocurarine, the tracheae were intubated and respiration was controlled. Urine was obtained for 90 minutes before induction, during induction, before, during and after bypass and post-operatively. Patients with TF had significantly higher pre-operative urine norepinephrine excretion rates than patients with ASD. In TF children anaesthetized with halothane norepinephrine excretion was significantly decreased during induction and during operation but increased post-operatively. Children with ASD and anaesthetized with halothane did not have urine norepinephrine excretion rates that were significantly different from pre-operative values until the postoperative period. ASD children anaesthetized with morphine had marked elevations in norepinephrine excretion during induction and all subsequent study periods. On the Other hand, morphine anaesthetized TF children did not have a significant increase in urine norepinephrine excretion until bypass had been established. Increased norepinephrine excretion was maintained in these patients during all subsequent study periods. These data, when combined with our results in patients with acquired heart disease, demonstrate that disease can alter norepinephrine responses to morphine anaesthesia. In addition our results suggest that dosage of morphine and morphine blood levels might also modify norepinephrine excretion. |
| تدمد: | 1496-8975 0008-2856 |
| DOI: | 10.1007/bf03004995 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4e73e6aada5c8c39dd40292f712d59 https://doi.org/10.1007/bf03004995 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0d4e73e6aada5c8c39dd40292f712d59 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14968975 00082856 |
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| DOI: | 10.1007/bf03004995 |