Effect of Ramipril Alone Compared to Ramipril with Eplerenone on Diabetic Nephropathy in Streptozocin-Induced Diabetic Rats
| العنوان: | Effect of Ramipril Alone Compared to Ramipril with Eplerenone on Diabetic Nephropathy in Streptozocin-Induced Diabetic Rats |
|---|---|
| المؤلفون: | Maria Mironidou-Tzouveleki, Angeliki Cheva, Thomas A. Mavrakanas, Konstantinos Kallaras, Georgios Karkavelas |
| المصدر: | Pharmacology. 86:85-91 |
| بيانات النشر: | S. Karger AG, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Ramipril, medicine.medical_specialty, Kidney Glomerulus, Angiotensin-Converting Enzyme Inhibitors, Spironolactone, Severity of Illness Index, Diabetes Mellitus, Experimental, Diabetic nephropathy, Random Allocation, chemistry.chemical_compound, Internal medicine, Diabetes mellitus, medicine, Animals, Diabetic Nephropathies, Rats, Wistar, Mineralocorticoid Receptor Antagonists, Pharmacology, Creatinine, business.industry, Hypertrophy, General Medicine, medicine.disease, Eplerenone, Glomerular Mesangium, Rats, Proteinuria, Endocrinology, chemistry, ACE inhibitor, Drug Therapy, Combination, business, Glomerular hyperfiltration, medicine.drug |
| الوصف: | Background/Aims: We studied the effect of the combined treatment with an angiotensin-converting enzyme (ACE) inhibitor (ramipril) and eplerenone compared with ramipril alone in streptozocin-induced diabetic rats. Methods: Wistar rats were divided into 4 groups: nondiabetic controls, streptozocin-treated diabetic rats (50 mg/kg), diabetic rats receiving ramipril (1 mg/kg) and diabetic rats treated with the combination of ramipril (1 mg/kg) and eplerenone (100 mg/kg) for 8 weeks. Our model produced early-stage diabetic nephropathy. Results: The diabetic rats developed polyuria, proteinuria, hyperfiltration (assessed by creatinine clearance) and histopathological evidence of renal injury including glomerular hypertrophy and mesangial expansion. Ramipril reduced proteinuria but its combination with eplerenone did not produce any greater benefit. Both treatment approaches prevented glomerular hypertrophy. Addition of eplerenone to ramipril prevented glomerular hyperfiltration. Conclusion: Whether eplerenone should be used in addition to an ACE inhibitor or an angiotensin receptor blocker at an early stage of diabetic nephropathy remains questionable. |
| تدمد: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000316113 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d039880215b5d20bada15ec7fca6c03 https://doi.org/10.1159/000316113 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0d039880215b5d20bada15ec7fca6c03 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230313 00317012 |
|---|---|
| DOI: | 10.1159/000316113 |