Usefulness of plasma B-type natriuretic peptide as a prognostic marker of cardiac function in senile systemic amyloidosis and in familial amyloidotic polyneuropathy
| العنوان: | Usefulness of plasma B-type natriuretic peptide as a prognostic marker of cardiac function in senile systemic amyloidosis and in familial amyloidotic polyneuropathy |
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| المؤلفون: | Hisayo Yasuda, Hisao Ogawa, Makoto Shono, Hiroki Usuku, Masayoshi Tasaki, Yukio Ando, Toshinori Oshima, Konen Obayashi |
| المصدر: | Amyloid. 20:251-255 |
| بيانات النشر: | Informa UK Limited, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Cardiac function curve, medicine.medical_specialty, medicine.drug_class, Diastole, Polyneuropathies, Troponin T, Internal medicine, Natriuretic Peptide, Brain, Internal Medicine, medicine, Natriuretic peptide, Humans, Prealbumin, Aged, Aged, 80 and over, biology, business.industry, Amyloidosis, C-reactive protein, medicine.disease, Transthyretin, C-Reactive Protein, Echocardiography, biology.protein, Cardiology, Female, business, Polyneuropathy |
| الوصف: | In senile systemic amyloidosis (SSA), a common age-related amyloidosis, wild-type transthyretin accumulates in tissues, with a primary result being cardiac dysfunction. Here, we aimed to clarify the usefulness of B-type natriuretic peptide (BNP) as a prognostic marker of cardiac function in SSA and in familial amyloidotic polyneuropathy (FAP).We studied 13 patients with severe SSA and 14 patients with FAP. SSA patients, but not FAP patients, demonstrated a significant correlation of log BNP with the echocardiographic diastolic marker E/e' ratio (r = 0.78, p0.01). SSA patients also showed significant correlations between log BNP and log C-reactive protein or log high-sensitive troponin T (r = 0.70, p0.01; r = 0.64, p0.05). FAP patients, however, had significant correlations between log BNP and left ventricular wall thickness (intraventricular septum thickness diastole and posterior wall thickness diastole) (r = 0.73, p0.01; r = 0.77, p0.01). The mean log BNP level in the follow-up period was significantly higher than that in the diagnostic period in SSA patients (2.65 ± 0.45 versus 2.36 ± 0.40, p0.01) but not in FAP patients (1.91 ± 0.56 versus 1.93 ± 0.45, p = 0.87). An especially notable phenomenon was the high plasma BNP level (≥180 pg/ml) in SSA patients.Plasma BNP levels may be a useful prognostic marker of cardiac function in SSA. |
| تدمد: | 1744-2818 1350-6129 |
| DOI: | 10.3109/13506129.2013.844122 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1a5e08fb479d1b462422bc8778d7c5 https://doi.org/10.3109/13506129.2013.844122 |
| رقم الانضمام: | edsair.doi.dedup.....0c1a5e08fb479d1b462422bc8778d7c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17442818 13506129 |
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| DOI: | 10.3109/13506129.2013.844122 |