Supplementary Methods + Figures from Therapeutic Inhibition of the MDM2–p53 Interaction Prevents Recurrence of Adenoid Cystic Carcinomas
| العنوان: | Supplementary Methods + Figures from Therapeutic Inhibition of the MDM2–p53 Interaction Prevents Recurrence of Adenoid Cystic Carcinomas |
|---|---|
| المؤلفون: | Jacques E. Nör, Shaomeng Wang, Manoel Sant'Ana Filho, Joseph I. Helman, Samuel A. Kerk, Alexander T. Pearson, Gerson A. Acasigua, Zhaocheng Zhang, Kristy A. Warner, Felipe Nör |
| بيانات النشر: | American Association for Cancer Research (AACR), 2023. |
| سنة النشر: | 2023 |
| الوصف: | Supplementary Materials and Methods: Immunohistochemistry, Immunofluorescence, TUNEL staining Supplementary Figure S1. Treatment with MI-773 and/or cisplatin is not toxic to mice. Graph depicting mouse weight during the experimental period. Data were normalized against pre-treatment weight. Supplementary Figure S2. Representative photomicrographs of UM-HACC-5 and -6 cells exposed to 1 μM MI-773 and/or 2 μM cisplatin, or vehicle control, for 72 hours in vitro. Supplementary Figure S3. Representative graphs depicting the number of UM-HACC-5 (A) and -6 (B) cells in each cell-cycle phase after treatment with 1 μM MI-773 and/or 2 μM cisplatin, or vehicle control, for 24 hours. Supplementary Figure S4. Representative photomicrographs obtained by immunofluorescence for ALDH (green) in UM-PDX-HACC-5 tumors treated with MI-773 and/or cisplatin. ALDH-positive cells are predominantly observed in vehicle and cisplatin groups (details) and are apparently located in close proximity to blood vessels (*) and nerve structures (N). Scale bar represents 50 μm (400x). |
| DOI: | 10.1158/1078-0432.22466907.v1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc3a04c7856ea7ed1bc951c82d6a341 https://doi.org/10.1158/1078-0432.22466907.v1 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0bc3a04c7856ea7ed1bc951c82d6a341 |
| قاعدة البيانات: | OpenAIRE |
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