Effects of resveratrol on the alterations of cavernosal eNOS and LOX-1 expression in the hypercholesterolemic condition: a preliminary study
| العنوان: | Effects of resveratrol on the alterations of cavernosal eNOS and LOX-1 expression in the hypercholesterolemic condition: a preliminary study |
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| المؤلفون: | Omer Demir, Aykut Kefi, Ahmet Adil Esen, Nergis Murat, Ozan Bozkurt, Sedef Gidener |
| المصدر: | Volume: 46, Issue: 4 1083-1088 Turkish Journal of Medical Sciences |
| بيانات النشر: | TÜBİTAK, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Nitric Oxide Synthase Type III, endocrine system diseases, Mrna expression, Hypercholesterolemia, 030232 urology & nephrology, Resveratrol, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Erectile Dysfunction, Enos, Internal medicine, Stilbenes, medicine, Animals, Statistical analysis, Beneficial effects, Messenger RNA, biology, business.industry, Dietary intake, food and beverages, General Medicine, Scavenger Receptors, Class E, biology.organism_classification, medicine.disease, Hypercholesterolemia,erectile dysfunction,resveratrol,eNOS,LOX-1, Endocrinology, Erectile dysfunction, chemistry, Rabbits, business, 030217 neurology & neurosurgery, Penis |
| الوصف: | Background/aim: The aim of this study was to determine the effects of resveratrol on the alterations of cavernosal eNOS and LOX-1 mRNA expression in the hypercholesterolemic condition. Materials and methods: Twenty-one New Zealand white male rabbits were separated into three groups. Rabbits were fed with a normal dietary intake for the control group and a 2% cholesterol diet for the hypercholesterolemia and resveratrol groups for 6 weeks. Resveratrol 4 mg/kg daily was administered for the resveratrol group. Cavernosal LOX-1 and eNOS mRNA expressions were determined with real-time RT-PCR in all groups. The statistical analysis was performed with the Kruskal?Wallis and Mann?Whitney U tests. Results: We found no difference between mean LOX-1 mRNA expression levels in the three groups. Lower mean eNOS mRNA expression level was determined in the hypercholesterolemia group when compared with the control group (P = 0.011). Mean eNOS mRNA expression level in the resveratrol group was similar to that in the control group but significantly higher than that in the hypercholesterolemia group (P < 0.001). Conclusion: This preliminary study demonstrates the beneficial effects of resveratrol on cavernosal eNOS expression. The presence of cavernosal LOX-1 expression was also shown for the first time. Resveratrol may be an alternative option in hypercholesterolemic erectile dysfunction with further studies supporting its beneficial effects on the corpus cavernosum. |
| وصف الملف: | application/pdf |
| تدمد: | 1300-0144 1303-6165 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb254c5928aa50c6549243595063449 https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45673/575876 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0bb254c5928aa50c6549243595063449 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13000144 13036165 |
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