Association study of HLA-B alleles with idiopathic male infertility in Han population of China
| العنوان: | Association study of HLA-B alleles with idiopathic male infertility in Han population of China |
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| المؤلفون: | Dang-xia Zhou, Wen-bao Zhao, Shui-ping Han, Yong-Wei Huo, Hong Tian, Jian Zhang, Jing Zhang, Zhao Tian, Hai-xu Wang, Xiao-fang Wang |
| المصدر: | Journal of Assisted Reproduction and Genetics. 28:979-985 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, China, medicine.medical_specialty, Genotype, Reproductive medicine, Biology, Male infertility, Gene Frequency, Genetics, medicine, HLA-B Antigens, Humans, Allele, Allele frequency, Genetic Association Studies, Infertility, Male, Genetics (clinical), Obstetrics and Gynecology, General Medicine, medicine.disease, Human genetics, HLA-B, Reproductive Medicine, Immunology, Developmental Biology |
| الوصف: | To investigate the distributions of HLA-B alleles and estimate their associations with idiopathic male infertility in Chinese Han population.Polymerase chain reaction-sequence-based typing (PCR-SBT) method was used for DNA typing at HLA-B locus in 109 patients with idiopathic male infertility and 152 healthy controls in male Han population of Shaanxi Province, situated in northwestern China.In total, we detected 45 HLA-B alleles in idiopathic infertile patients, 48 HLA-B alleles in control subjects. However, no significant differences of these allelic frequencies were found between the infertile patients and the controls.HLA-B gene was unlikely a major risk factor of idiopathic male infertility in this sample population. As different populations have different HLA polymorphisms, investigation of the relationship of other HLA genes and idiopathic male infertility with larger sample size, is warranted in the future. |
| تدمد: | 1573-7330 1058-0468 |
| DOI: | 10.1007/s10815-011-9622-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7847c8b3730c6297eddf24d16a032e https://doi.org/10.1007/s10815-011-9622-9 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0b7847c8b3730c6297eddf24d16a032e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737330 10580468 |
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| DOI: | 10.1007/s10815-011-9622-9 |