Colonic diverticular disease in autosomal dominant polycystic kidney disease: is there really an association? A nationwide analysis
| العنوان: | Colonic diverticular disease in autosomal dominant polycystic kidney disease: is there really an association? A nationwide analysis |
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| المؤلفون: | Jill Stoltzfus, Noel Martins, Santo Longo, Yecheskel Schneider, Rodrigo Duarte-Chavez, Vikas Yellapu, Berhanu Geme, Sudip Nanda |
| المصدر: | International Journal of Colorectal Disease. 36:83-91 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Constipation, Population, Autosomal dominant polycystic kidney disease, 030230 surgery, urologic and male genital diseases, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Diverticulosis, Colonic, medicine, Humans, education, Diverticulitis, Diverticular Diseases, education.field_of_study, urogenital system, business.industry, digestive, oral, and skin physiology, Odds ratio, Hepatology, Polycystic Kidney, Autosomal Dominant, medicine.disease, Kidney Transplantation, digestive system diseases, female genital diseases and pregnancy complications, Diverticulosis, 030220 oncology & carcinogenesis, Diverticular disease, medicine.symptom, business |
| الوصف: | Colonic diverticulosis, diverticulitis, and diverticular bleeding are reportedly more common in patients with autosomal dominant polycystic kidney disease (ADPKD). Other studies have questioned this association. The objectives of our study are to clarify this association using a larger patient population and to identify risk factors in general to develop diverticular disease. The Nationwide Inpatient Sample weighted discharges from 2003 to 2011 were used to assess for the prevalence of diverticular disease in the population with ADPKD compared with the general population without ADPKD. A multivariable direct logistic regression model was constructed to determine independent predictors of diverticular disease in the general population. The prevalence of diverticulosis, diverticulitis, and diverticular bleeding were considerably increased in patients with ADPKD compared with the general population without ADPKD. The prevalence of colonic surgery was less in ADPKD patients with diverticulitis. In patients with kidney transplant, the prevalence of diverticulitis was increased in the ADPKD group, but colonic surgery was not significantly different between both groups. The prevalence of diverticular bleeding was slightly elevated in patients with ADPKD, but colonic surgery was significantly increased in patients with ADPKD. NSAID use, hypertension, constipation, and ADPKD had increased odds ratios for diverticular disease during multivariate analysis. There is an increased prevalence of colonic diverticular disease in the population with ADPKD. |
| تدمد: | 1432-1262 0179-1958 |
| DOI: | 10.1007/s00384-020-03736-2 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4adb0857b06d81ca95d2c7dec4feb4 https://doi.org/10.1007/s00384-020-03736-2 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0b4adb0857b06d81ca95d2c7dec4feb4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321262 01791958 |
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| DOI: | 10.1007/s00384-020-03736-2 |