Balanced and unbalanced chromosomal translocations in myelodysplastic syndromes: clinical and prognostic significance
| العنوان: | Balanced and unbalanced chromosomal translocations in myelodysplastic syndromes: clinical and prognostic significance |
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| المؤلفون: | Gioia Colafigli, Francesca Fazio, M.Z. Limongi, Eleonora Sangiorgi, Emilia Scalzulli, Matteo Molica, Roberto Latagliata, Annalina Piccioni, Maria Antonietta Aloe Spiriti, Marco Mancini, Ida Carmosino, Sara Mohamed, Serena Rosati, Alessia Campagna, Maria Lucia De Luca, Stefania Nigro, Daniela De Benedittis, Massimo Breccia, Elena Mariggiò, Mauro Nanni |
| المصدر: | Leukemia & Lymphoma. 61:3476-3483 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, education, Chromosomal translocation, Translocation, Genetic, 03 medical and health sciences, 0302 clinical medicine, health services administration, hemic and lymphatic diseases, Internal medicine, Humans, Medicine, Retrospective Studies, Chromosome Aberrations, business.industry, Myelodysplastic syndromes, Karyotype, Hematology, Prognosis, medicine.disease, humanities, Myelodysplastic Syndromes, 030220 oncology & carcinogenesis, population characteristics, business, 030215 immunology |
| الوصف: | Prognostic role of chromosomal translocations (CT) in myelodysplasia (MDS) was retrospectively analyzed in 77 patients from GROM-L registry. Forty (51.9%) balanced, 28 (36.4%) unbalanced and 9 (11.7%) concomitant balanced and unbalanced CT were identified. Five-year overall survival (OS) of the entire cohort was 34.5% (CI 95% 22.5-46.5). Five-year OS of patients with unbalanced CT was significantly shorter than that of patients carrying balanced CT [22.3% (CI 95% 4.0-40.6) vs 44.0% (CI 95% 26.7-61.3) ( |
| تدمد: | 1029-2403 1042-8194 |
| DOI: | 10.1080/10428194.2020.1811861 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3e432c7813d6aec98cadcb0d5cd06d https://doi.org/10.1080/10428194.2020.1811861 |
| رقم الانضمام: | edsair.doi.dedup.....0b3e432c7813d6aec98cadcb0d5cd06d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10292403 10428194 |
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| DOI: | 10.1080/10428194.2020.1811861 |