التفاصيل البيبلوغرافية
| العنوان: |
Lung histopathological pattern in a survivor with rapidly progressive interstitial lung disease and anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis |
| المؤلفون: |
Tomoki Kimura, Yasuhiro Kondoh, Mikiko Hashisako, Kazuhiko Tabata, Kenzo Ono, Atsushi Suzuki, Kensuke Kataoka, Junya Fukuoka, Hiroyuki Taniguchi |
| المصدر: |
Respiratory Medicine Case Reports |
| بيانات النشر: |
The Authors. Published by Elsevier Ltd. |
| مصطلحات موضوعية: |
Pulmonary and Respiratory Medicine, MDA5, melanoma differentiation-associated gene 5, Vital capacity, Pathology, medicine.medical_specialty, CADM, MDA5, Lung histopathological pattern, Case Report, IVCY, intravenous cyclophosphamide, 03 medical and health sciences, FEV1/FVC ratio, 0302 clinical medicine, DLCO, CADM, clinically amyopathic dermatomyositis, RP-ILD, rapidly progressive interstitial lung disease, medicine, DAD, Diffuse alveolar damage, 030203 arthritis & rheumatology, Lung, 6MWD, six-min walk distance, NSIP, nonspecific interstitial pneumonia, business.industry, Interstitial lung disease, DLco, diffusing capacity of the lung for carbon monoxide, Dermatomyositis, respiratory system, medicine.disease, MMRC, modified medical research council dyspnea scale, CT, computed tomography, respiratory tract diseases, medicine.anatomical_structure, 030228 respiratory system, Immunology, FVC, forced vital capacity, DAD, diffuse alveolar damage, RP-ILD, business |
| الوصف: |
Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are specific indicators of patients with dermatomyositis, particularly clinically amyopathic dermatomyositis (CADM). CADM is occasionally accompanied by fatal, treatment-resistant, rapidly-progressive interstitial lung disease (RP-ILD). All previous reports showed that histopathological findings in RP-ILD with anti-MDA5 antibody-positive CADM indicated diffuse alveolar damage (DAD). This is the first report describing a non-DAD pattern in RP-ILD with anti-MDA5 antibody-positive CADM, which was improved by immunosuppressive therapy. This case may be a milder clinical phenotype than a typical DAD pattern in RP-ILD with anti-MDA5 antibody-positive CADM. |
| اللغة: |
English |
| تدمد: |
2213-0071 |
| DOI: |
10.1016/j.rmcr.2016.05.008 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac435c0df3544a8b13130da9777e324 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....0ac435c0df3544a8b13130da9777e324 |
| قاعدة البيانات: |
OpenAIRE |