Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis
| العنوان: | Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis |
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| المؤلفون: | Giulia Scioscia, Massimo Conese, Lucia Catucci, Filomena Simone, Maria P. Foschino-Barbaro, Donato Lacedonia, Grazia Pia Palladino, Piera Soccio, Roberto Rana, Carla Maria Irene Quarato, Francesco Sollitto, Sante Di Gioia |
| المصدر: | BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-8 (2021) BMC Pulmonary Medicine |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Down-Regulation, Idiopathic pulmonary fibrosis, Disease, Exosomes, Pathogenesis, 03 medical and health sciences, Diseases of the respiratory system, 0302 clinical medicine, Internal medicine, microRNA, medicine, Humans, Lung, Pathological, Aged, 030304 developmental biology, 0303 health sciences, RC705-779, business.industry, Interstitial lung disease, Middle Aged, medicine.disease, Pathophysiology, MicroRNAs, Cross-Sectional Studies, Gene Expression Regulation, 030228 respiratory system, Case-Control Studies, Biomarker (medicine), Female, business, Biomarkers, Research Article, Signal Transduction |
| الوصف: | Background Idiopathic Pulmonary Fibrosis (IPF) is a degenerative interstitial lung disease with both a poor prognosis and quality of life once the diagnosis is made. In the last decade many features of the disease have been investigated to better understand the pathological steps that lead to the onset of the disease and, moreover, different types of biomarkers have been tested to find valid diagnostic, prognostic and therapy response predictive ones. In the complexity of IPF, microRNA (miRNAs) biomarker investigation seems to be promising. Methods We analysed the expression of five exosomal miRNAs supposed to have a role in the pathogenesis of the disease from serum of a group of IPF patients (n = 61) and we compared it with the expression of the same miRNAs in a group of healthy controls (n = 15). Results In the current study what emerged is let-7d down-regulation and, unexpectedly, miR-16 significant down-regulation. Moreover, through a cross-sectional analysis, a clustering of the expression of miR-16, miR-21 and miR-26a was found. Conclusions These findings could help the individuation of previously unknown key players in the pathophysiology of IPF and, most interestingly, more specific targets for the development of effective medications. |
| اللغة: | English |
| تدمد: | 1471-2466 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a758cfb0150c59e9a39ff8e028d34e9 https://doaj.org/article/e588548855dc4c4397ca9668a04f3282 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0a758cfb0150c59e9a39ff8e028d34e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712466 |
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