Tigecycline in febrile neutropenic patients with haematological malignancies: a retrospective case documentation in four university hospitals
| العنوان: | Tigecycline in febrile neutropenic patients with haematological malignancies: a retrospective case documentation in four university hospitals |
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| المؤلفون: | C. M. Nellessen, Ulrich Germing, Werner J. Heinz, Axel Glasmacher, K. S. Schwab, Günter Marklein, M. von Lilienfeld-Toal, Peter Brossart, C. Leyendecker, Gerlinde Egerer, Corinna Hahn-Ast |
| المصدر: | Infection. 42:97-104 |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Microbiology (medical), medicine.medical_specialty, Drug-Related Side Effects and Adverse Reactions, medicine.drug_class, Antibiotics, Salvage therapy, Minocycline, Tigecycline, Glycylcycline, Hospitals, University, Internal medicine, medicine, Humans, Chemotherapy-Induced Febrile Neutropenia, Intensive care medicine, Aged, Retrospective Studies, business.industry, Critically ill, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, University hospital, Anti-Bacterial Agents, Treatment Outcome, Infectious Diseases, Hematologic Neoplasms, Female, business, Febrile neutropenia, medicine.drug |
| الوصف: | Tigecycline (TGC) is a first-in-class glycylcycline with an expanded spectrum of activity. Although TGC has not been prospectively studied in febrile neutropenia (FN), we observed that occasionally critically ill neutropenic patients unresponsive to other antibiotics were treated with TGC in our departments. The aim of our study was to analyse effectiveness and toxicity of TGC in FN.Data of infectious episodes treated with TGC were retrospectively collected. Baseline data of patients, haematological malignancy, infection and adverse events were documented. Success was defined as defervescence (≥7 days) in the absence of any sign of persistent infection.Data of 35 patients with haematological malignancies and FN were evaluated. Median duration of neutropenia was 25 days (range 6-69 days). The type of infection was pneumonia in 24 patients, four microbiologically documented infections, three clinically documented infections and four with fever of unknown origin. The TGC was administered after a median of two (range 1-5) prior antibiotic regimens. Treatment was successful in 15 (43 %) patients. In patients with prolonged neutropenia (≥28 days), response was significantly lower (13 vs. 79 %; p =0.001). Eight (23 %) patients died during the fever episode. Grade 3-4 toxicity occurred in five (14 %) patients.Our results showed promising response rates to TGC and very low toxicity rates compared to the generally low response rate of third-line antibiotic therapies, indicating that TGC may be a successful alternative for salvage treatment of febrile neutropenia, but further study is needed. |
| تدمد: | 1439-0973 0300-8126 |
| DOI: | 10.1007/s15010-013-0524-x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2b5af7c6b44bdc83e24a9f65558b56 https://doi.org/10.1007/s15010-013-0524-x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0a2b5af7c6b44bdc83e24a9f65558b56 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390973 03008126 |
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| DOI: | 10.1007/s15010-013-0524-x |