Clinical implications of malnutrition in childhood cancer patients—infections and mortality
| العنوان: | Clinical implications of malnutrition in childhood cancer patients—infections and mortality |
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| المؤلفون: | Wim J. E. Tissing, Aeltsje Brinksma, Erik A. H. Loeffen, de Truuske Bock, Karin G. E. Miedema |
| المساهمون: | Damage and Repair in Cancer Development and Cancer Treatment (DARE), Life Course Epidemiology (LCE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE) |
| المصدر: | Supportive Care in Cancer, 23(1), 143-150. SPRINGER |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Weight loss, NUTRITIONAL-STATUS, medicine.medical_specialty, Neutropenia, Adolescent, Survival, Population, Nutritional Status, Bacteremia, CHILDREN, DIAGNOSIS, Pediatrics, THERAPY, Body Mass Index, Neoplasms, Internal medicine, Odds Ratio, medicine, Humans, Child, Intensive care medicine, education, Cancer, ACUTE LYMPHOBLASTIC-LEUKEMIA, education.field_of_study, business.industry, Incidence, Incidence (epidemiology), Malnutrition, Hazard ratio, Infant, Odds ratio, Prognosis, medicine.disease, Oncology, Child, Preschool, Female, medicine.symptom, Infection, business, Body mass index |
| الوصف: | In childhood cancer patients, malnutrition has been proposed to increase infection rates and reduce survival. We investigated whether malnutrition at diagnosis and during treatment and weight loss during treatment are prognostic factors for infection rates and survival, within a heterogeneous childhood cancer population.From two previous studies, all children a parts per thousand currency sign18 years of age diagnosed with cancer between October 2004 and October 2011 were included in this study. Data regarding BMI, infections, and survival were retrieved. Patients with a BMI z-score lower than -2.0 were classified as malnourished. Weight loss more than 5 % was considered relevant.Two hundred sixty-nine childhood cancer patients were included in this study. At diagnosis, 5.2 % of all patients were malnourished. These patients showed worse survival than those who were well nourished (hazard ratio (HR) = 3.63, 95 % confidence interval (CI) = 1.52-8.70, p = 0.004). Malnourishment at 3 months after diagnosis (3.3 % of all patients) also showed worse survival (HR = 6.34, 95 % CI = 2.42-16.65, p We found that malnourishment in the initial phase of therapy is associated with worse survival in childhood cancer patients. In addition, we found for the first time that weight loss during treatment is associated with increased presence of febrile neutropenic episodes with bacteremia. This underlines the importance of optimal feeding designs in childhood cancer patients. |
| تدمد: | 1433-7339 0941-4355 |
| DOI: | 10.1007/s00520-014-2350-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a23ed4f7376611170b88cfb193cbaf3 https://doi.org/10.1007/s00520-014-2350-9 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0a23ed4f7376611170b88cfb193cbaf3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14337339 09414355 |
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| DOI: | 10.1007/s00520-014-2350-9 |