Vascular hamartoma in the central nervous system of a foal
| العنوان: | Vascular hamartoma in the central nervous system of a foal |
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| المؤلفون: | Hannah K Junge, Meret Wehrli Eser, Paula Grest, Nicole Borel |
| المساهمون: | University of Zurich, Borel, N |
| المصدر: | Journal of Veterinary Diagnostic Investigation. 26:805-809 |
| بيانات النشر: | SAGE Publications, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Vascular Hamartoma, 3400 General Veterinary, Hamartoma, 10184 Institute of Veterinary Pathology, Foals, obex, Biology, Obex Region, Fatal Outcome, biology.animal, Parenchyma, Paralysis, medicine, Animals, Horses, Brain Diseases, Fourth Ventricle, General Veterinary, Glial fibrillary acidic protein, nerve deficits, Anatomy, medicine.disease, Immunohistochemistry, Animals, Newborn, Foal, Laryngeal paralysis, biology.protein, 570 Life sciences, biology, Horse Diseases, 10090 Equine Department, medicine.symptom |
| الوصف: | Vascular hamartomas are non-neoplastic developmental anomalies of vessels. Cases of cerebral vascular hamartomas have been previously reported in dogs and cats. A 4-week-old Freiberger foal had shown persistent problems with breathing and swallowing since birth, and bilateral laryngeal paralysis was diagnosed. The foal subsequently developed left sided facial nerve paralysis and a secondary corneal ulcer in the left eye. Necropsy revealed a pinkish mass in the obex region of the brain. The mass was further investigated by histology and immunohistochemistry. Histologically, the mass consisted of many thin-walled, blood-filled vascular structures of variable diameter involving the white matter of the obex. The lining cells were immunohistochemically positive for factor VIII (von Willebrand factor) interpreted as endothelial cells. The endothelial lining showed also variable immunoreactivity for smooth muscle actin and vimentin. Normal neural parenchyma labeled with antibodies directed against glial fibrillary acidic protein and neuron-specific enolase was present between the vascular proliferations. A diagnosis of focal vascular hamartoma in the obex was made. The development of clinical signs is attributed to the compression of the surrounding neural parenchyma. |
| وصف الملف: | J VET Diagn Invest-2014-Borel-1040638714548681.pdf - application/pdf |
| تدمد: | 1943-4936 1040-6387 |
| DOI: | 10.1177/1040638714548681 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b1d1f867f75ea034227bab80b163ab https://doi.org/10.1177/1040638714548681 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....09b1d1f867f75ea034227bab80b163ab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19434936 10406387 |
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| DOI: | 10.1177/1040638714548681 |