A randomized, crossover, placebo controlled, double-blind trial of the effects of tiotropium-olodaterol on neuromuscular performance during exercise in COPD
| العنوان: | A randomized, crossover, placebo controlled, double-blind trial of the effects of tiotropium-olodaterol on neuromuscular performance during exercise in COPD |
|---|---|
| المؤلفون: | Min Cao, Robert A. Calmelat, Peter Kierstead, Nicolo Carraro, William W. Stringer, Janos Porszasz, Richard Casaburi, Harry B. Rossiter |
| المصدر: | Journal of Applied Physiology. 132:1145-1153 |
| بيانات النشر: | American Physiological Society, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Cross-Over Studies, Physiology, Muscarinic Antagonists, Benzoxazines, Bronchodilator Agents, respiratory tract diseases, Drug Combinations, Pulmonary Disease, Chronic Obstructive, Physiology (medical), Humans, Female, Tiotropium Bromide, Fatigue |
| الوصف: | Bronchodilation is known to increase forced expiratory volume in 1 s (FEV1) and reduce hyperinflation in COPD. In a randomized controlled trial, we investigated whether combined inhaled long-acting β-agonist and muscarinic antagonist would alleviate maximal voluntary neuromuscular performance fatigue or enhance maximal muscle activation during cycling in patients with COPD. Despite increased FEV1, combination bronchodilator therapy did not reduce neuromuscular performance fatigue or enhance muscle activity or exercise tolerance in patients with mild-to-severe COPD. |
| تدمد: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00332.2021 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09973f3d144b700cf98dd8ef149a17b5 https://doi.org/10.1152/japplphysiol.00332.2021 |
| رقم الانضمام: | edsair.doi.dedup.....09973f3d144b700cf98dd8ef149a17b5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221601 87507587 |
|---|---|
| DOI: | 10.1152/japplphysiol.00332.2021 |