A Ten-Day Grape Seed Procyanidin Treatment Prevents Certain Ageing Processes in Female Rats over the Long Term
| العنوان: | A Ten-Day Grape Seed Procyanidin Treatment Prevents Certain Ageing Processes in Female Rats over the Long Term |
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| المؤلفون: | Ximena Terra, Montserrat Pinent, Anna Ardévol, Esther Rodríguez-Gallego, Marta Sierra-Cruz, Raúl Beltrán-Debón, Carme Grau-Bové, Mayte Blay, Alba Miguéns-Gómez |
| المصدر: | Nutrients Nutrients, Vol 12, Iss 3647, p 3647 (2020) Volume 12 Issue 12 |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, tumor, Aging, food intake, Time Factors, medicine.medical_treatment, Osteoporosis, Physiology, lcsh:TX341-641, Glucagon, Article, Drug Administration Schedule, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, medicine, Animals, Proanthocyanidins, Rats, Wistar, adiposity, Nutrition and Dietetics, Grape Seed Extract, business.industry, Insulin, glucagon/insulin, Body Weight, procyanidins, medicine.disease, Rats, 030104 developmental biology, medicine.anatomical_structure, Ageing, ageing, Sarcopenia, Body Composition, Female, Pancreas, business, lcsh:Nutrition. Foods and food supply, 030217 neurology & neurosurgery, Homeostasis, Food Science |
| الوصف: | Adaptive homeostasis declines with age and this leads to, among other things, the appearance of chronic age-related pathologies such as cancer, neurodegeneration, osteoporosis, sarcopenia, cardiovascular disease and diabetes. Grape seed-derived procyanidins (GSPE) have been shown to be effective against several of these pathologies, mainly in young animal models. Here we test their effectiveness in aged animals: 21-month-old female rats were treated with 500 mg GSPE/kg of body weight for ten days. Afterwards they were kept on a chow diet for eleven weeks. Food intake, body weight, metabolic plasma parameters and tumor incidence were measured. The GSPE administered to aged rats had an effect on food intake during the treatment and after eleven weeks continued to have an effect on visceral adiposity. It prevented pancreas dysfunction induced by ageing and maintained a higher glucagon/insulin ratio together with a lower decrease in ketonemia. It was very effective in preventing age-related tumor development. All in all, this study supports the positive effect of GSPE on preventing some age-related pathologies. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098f561e27d1eb9a8599da4efa0b9149 http://europepmc.org/articles/PMC7759988 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....098f561e27d1eb9a8599da4efa0b9149 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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