Secretogranin II is overexpressed in advanced prostate cancer and promotes the neuroendocrine differentiation of prostate cancer cells
| العنوان: | Secretogranin II is overexpressed in advanced prostate cancer and promotes the neuroendocrine differentiation of prostate cancer cells |
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| المؤلفون: | Fatima-Zohra El Yamani, Afaf Amarti, Rabia Magoul, Youssef Anouar, Hinde El Fatemi, Fadl Tazi, Maité Montero-Hadjadje, Maïté Courel, Nicolas Chartrel, Charlène Delestre, David Alexandre |
| المساهمون: | Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), ARC association for cancer research, Conseil Regional de Haute Normandie, Inserm, (U982), University of Rouen, Plateforme Regionale de Recherche en Imagerie Cellulaire de Haute-Normandie (PRIMACEN), Compartimentation et trafic intracellulaire des mRNP = Compartmentation and intracellular traffic of mRNPs (LBD-E14), Laboratoire de Biologie du Développement (LBD), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | European Journal of Cancer European Journal of Cancer, Elsevier, 2014, 50 (17), pp.3039-3049. ⟨10.1016/j.ejca.2014.09.009⟩ |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Oncology, Male, Cancer Research, [SDV]Life Sciences [q-bio], [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], urologic and male genital diseases, Neuroendocrine differentiation, Prostate cancer, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Neuropeptide Y, Secretory granule, [SDV.BDD]Life Sciences [q-bio]/Development Biology, [SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN], Hyperplasia, 3. Good health, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Prostate-specific antigen, Cell Transformation, Neoplastic, Secretogranin II, Androgens, Disease Progression, Steroids, Secretogranin, medicine.medical_specialty, medicine.drug_class, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Secretogranin, Secretory granule, Neuroendocrine differentiation, Prostate cancer, Internal medicine, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Cell Line, Tumor, LNCaP, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], business.industry, Cancer, Prostatic Neoplasms, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Androgen Antagonists, Prostate-Specific Antigen, medicine.disease, Androgen, Culture Media, Secretory protein, business |
| الوصف: | International audience; Aim: In prostate cancer (PCa), neuroendocrine differentiation (NED) is commonly observed in relapsing, hormone therapy-resistant tumours after androgen deprivation. However, the molecular mechanisms involved in the NED of PCa cells remain poorly understood. In this study, we investigated the expression of the neuroendocrine secretory protein secretogranin II (SgII) in PCa, and its potential involvement in the progression of this cancer as a granulogenic factor promoting NED. Methods: We have examined SgII immunoreactivity in 25 benign prostate hyperplasia and 32 PCa biopsies. In vitro experiments were performed to investigate the involvement of SgII in the neuroendocrine differentiation and the proliferation of PCa cell lines. Results: We showed that immunoreactive SgII intensity correlates with tumour grade in PCa patients. Using the androgen-dependent lymph node cancer prostate cells (LNCaP) cells, we found that NED triggered by androgen deprivation is associated with the induction of SgII expression. In addition, forced expression of SgII in LNCaP cells implemented a regulated secretory pathway by triggering the formation of secretory granule-like structures competent for hormone storage and regulated release. Finally, we found that SgII promotes prostate cancer (CaP) cell proliferation. Conclusion: The present data show that SgII is highly expressed in advanced PCa and may contribute to the neuroendocrine differentiation by promoting the formation of secretory granules and the proliferation of PCa cells. (C) 2014 Elsevier Ltd. All rights reserved. |
| تدمد: | 1879-0852 0959-8049 |
| DOI: | 10.1016/j.ejca.2014.09.009⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094db9a83dee080f8063f39ad818dc00 https://pubmed.ncbi.nlm.nih.gov/25307750 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....094db9a83dee080f8063f39ad818dc00 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18790852 09598049 |
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| DOI: | 10.1016/j.ejca.2014.09.009⟩ |