Wnt/β-catenin signaling pathway in severe preeclampsia
| العنوان: | Wnt/β-catenin signaling pathway in severe preeclampsia |
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| المؤلفون: | Linlin Zhang, Xiaofang Wang, Xianxu Zeng, Wanyu Song, Zhan Zhang, Jinming Wang, Ying Shi |
| المصدر: | Journal of Molecular Histology. 49:317-327 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, animal structures, Histology, Beta-catenin, Physiology, Placenta, Biology, Andrology, 03 medical and health sciences, Pre-Eclampsia, Western blot, Pregnancy, GSK-3, medicine, Humans, Wnt Signaling Pathway, beta Catenin, medicine.diagnostic_test, Wnt signaling pathway, Cell Biology, General Medicine, Trophoblasts, 030104 developmental biology, medicine.anatomical_structure, DKK1, Case-Control Studies, embryonic structures, biology.protein, Intercellular Signaling Peptides and Proteins, Immunohistochemistry, Female, Signal transduction |
| الوصف: | This study aims to elucidate the mechanisms of Wnt/β-catenin signaling pathway in the development of preeclampsia (PE). The mRNA levels of Wnt1, β-catenin, c-myc and cyclinD1 were determined by real-time PCR in the placentas. Moreover, the expression levels of Wnt1, β-catenin, Dickkopf-1 (DKK1) and glycogen synthase kinase 3β (GSK-3β) proteins were detected by Western blot. Immunohistochemistry was used in placental tissue microarray to localize the expression of Wnt1, β-catenin, DKK1 proteins in the placentas of two groups. Compared with the control placentas, the mRNA levels of Wnt1, β-catenin, c-myc and cyclinD1 were decreased in the severe preeclamptic placentas. The Western blot results showed that the expression levels of Wnt1, β-catenin, and GSK-3β proteins were significantly elevated in the control group, while the expression level of DKK1 was significantly decreased. In addition, the staining intensity of Wnt1, β-catenin were weaker in the placentas of the severe PE group while the staining intensity of DKK1 was significantly stronger in the placentas of the severe PE group. Wnt/β-catenin signaling pathway may play a significant role in the pathogenesis of PE by regulating the invasion and proliferation of trophoblast. |
| تدمد: | 1567-2387 1567-2379 |
| DOI: | 10.1007/s10735-018-9770-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0945426a444b8b449ec4a53480e95c73 https://doi.org/10.1007/s10735-018-9770-7 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0945426a444b8b449ec4a53480e95c73 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15672387 15672379 |
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| DOI: | 10.1007/s10735-018-9770-7 |