Effect of gonadotropin-releasing hormone agonist treatment in boys with central precocious puberty: final height results

التفاصيل البيبلوغرافية
العنوان: Effect of gonadotropin-releasing hormone agonist treatment in boys with central precocious puberty: final height results
المؤلفون: Dick Mul, G Saggese, J L Chaussain, Silvano Bertelloni, Wilma Oostdijk, Jean Claude Carel
المساهمون: Pediatrics
المصدر: Hormone Research, 58, 1-7. Karger
سنة النشر: 2002
مصطلحات موضوعية: Agonist, Male, medicine.medical_specialty, Antineoplastic Agents, Hormonal, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Central precocious puberty, Puberty, Precocious, Gonadotropin-Releasing Hormone, Endocrinology, Internal medicine, Gonadotropin-releasing hormone agonist, medicine, Precocious puberty, Humans, Child, Netherlands, Retrospective Studies, Triptorelin Pamoate, business.industry, Final height, medicine.disease, Body Height, Italy, Pediatrics, Perinatology and Child Health, France, business, Hormone
الوصف: Objective: The small number of boys present in most studies on final height (FH) after gonadotropin-releasing hormone agonist (GnRHa) treatment for central precocious puberty (CPP) offers difficulties in the evaluation of the effects of treatment on FH in males. Method: We therefore combined FH data from The Netherlands, Italy and France to study the effect of GnRHa treatment in a large group of 26 boys with CPP. Results: The mean chronological age at the start of treatment was 7.6 ± 2.0 (SD) years, bone age (BA) was 11.0 ± 2.1 years. All boys were treated with depot formulations of the GnRHa triptorelin with established gonadal suppression for a mean treatment period of 4.7 ± 2.1 years. FH was 172.9 ± 6.6 cm. FH standard deviation score (SDS) was –0.66 ± 1.22, not significantly different from the target height SDS of –0.23 ± 0.75. FH-SDS was significantly lower in the subgroup of 12 patients with organic CPP compared to patients with idiopathic CPP (–1.34 ± 1.06 vs. –0.08 ± 1.06, respectively; p = 0.01), but no difference in height gain was observed. The mean estimated height gain, defined as the difference between predicted and actual adult height was 6.2 ± 8.7 cm using the average tables of Bayley and Pinneau, and 0.3 ± 8.6 cm using the BA advance adjusted tables. Regional differences in height gain were observed between the different countries, reflecting different local practices. Conclusion: We conclude that GnRHa treatment in boys results in a FH close to target height.
تدمد: 0301-0163
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087981d118f7a232b754a394a532522a
https://hdl.handle.net/1765/65461
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....087981d118f7a232b754a394a532522a
قاعدة البيانات: OpenAIRE