The genetic basis of inbreeding depression in potato
| العنوان: | The genetic basis of inbreeding depression in potato |
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| المؤلفون: | Canhui Li, Sanwen Huang, Zhongmin Yang, Jianjian Qi, Nilesh R. Tawari, Die Tang, Yi Shang, Fei Lu, Chunzhi Zhang, Pei Wang |
| المصدر: | Nature Genetics. 51:374-378 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Genotype, Plant genetics, Biology, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Inbred strain, Genetics, medicine, Inbreeding depression, Allele, Gene, Alleles, Solanum tuberosum, 030304 developmental biology, 0303 health sciences, Mutation, Inbreeding Depression, fungi, food and beverages, Genomics, Diploidy, Plant Breeding, Ploidy, Genome, Plant, 030217 neurology & neurosurgery |
| الوصف: | Inbreeding depression confers reduced fitness among the offspring of genetic relatives. As a clonally propagated crop, potato (Solanum tuberosum L.) suffers from severe inbreeding depression; however, the genetic basis of inbreeding depression in potato is largely unknown. To gain insight into inbreeding depression in potato, we evaluated the mutation burden in 151 diploid potatoes and obtained 344,831 predicted deleterious substitutions. The deleterious mutations in potato are enriched in the pericentromeric regions and are line specific. Using three F2 populations, we identified 15 genomic regions with severe segregation distortions due to selection at the gametic and zygotic stages. Most of the deleterious recessive alleles affecting survival and growth vigor were located in regions with high recombination rates. One of these deleterious alleles is derived from a rare mutation that disrupts a gene required for embryo development. This study provides the basis for genome design of potato inbred lines. |
| تدمد: | 1546-1718 1061-4036 |
| DOI: | 10.1038/s41588-018-0319-1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086fc04e8298e6af00eb7ac5c2901e65 https://doi.org/10.1038/s41588-018-0319-1 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....086fc04e8298e6af00eb7ac5c2901e65 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15461718 10614036 |
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| DOI: | 10.1038/s41588-018-0319-1 |