Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents

التفاصيل البيبلوغرافية
العنوان: Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents
المؤلفون: Zafer Asim Kaplancikl, Yusuf Özkay, Derya Osmaniye, Ulviye Acar Çevik, Serkan Levent, Betül Kaya Çavuşoğlu, Begüm Nurpelin Sağlık
المساهمون: Anadolu Üniversitesi
المصدر: Heterocyclic Communications, Vol 26, Iss 1, Pp 6-13 (2020)
بيانات النشر: Walter De Gruyter Gmbh, 2020.
سنة النشر: 2020
مصطلحات موضوعية: C-13-NMR, 1h-nmr, MTT assay, Series (mathematics), 010405 organic chemistry, Chemistry, Organic Chemistry, 1,3,4-Thiadiazole, Carbon-13 NMR, 01 natural sciences, Combinatorial chemistry, 13c-nmr, H-1-NMR, 0104 chemical sciences, Characterization (materials science), lcsh:QD241-441, 010404 medicinal & biomolecular chemistry, Anticancer, lcsh:Organic chemistry, Proton NMR
الوصف: WOS: 000518798900001
Cancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs are major problems in chemotherapy. Nowadays the aim of many medical research projects is to discover new safer and more effective anticancer agents. 1,3,4-Thiadiazole compounds are important fragments in medicinal chemistry because of their wide range of biological activities, including anticancer activities. the aim of this study was to determine the capacity of newly synthesized 1,3,4-thiadiazole compounds as chemotherapeutic agents. the structures of the obtained compounds were elucidated using H-1-NMR, C-13-NMR and mass spectrometry. Although the thiadiazole derivatives did not prove to be significantly cytotoxic to the tumour tissue cultures, compound 4i showed activity against the C6 rat brain cancer cell line (IC50 0.097 mM) at the tested concentrations.
Anadolu University Scientific Projects Fund [1903S016]
This study was financially supported by Anadolu University Scientific Projects Fund, Project No: 1903S016.
اللغة: English
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086ccd92e340f3a0f37d893929841afd
https://hdl.handle.net/11421/24028
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....086ccd92e340f3a0f37d893929841afd
قاعدة البيانات: OpenAIRE