Selective Perioperative Administration of Pasireotide is More Cost-Effective Than Routine Administration for Pancreatic Fistula Prophylaxis
| العنوان: | Selective Perioperative Administration of Pasireotide is More Cost-Effective Than Routine Administration for Pancreatic Fistula Prophylaxis |
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| المؤلفون: | Morgan L. Bruno, Jason B. Fleming, Rebecca Slack, Michael P. Kim, Jean Nicolas Vauthey, Thomas A. Aloia, Laura R. Prakash, Jeffrey E. Lee, Jason W. Denbo, Matthew H.G. Katz, Jordan M. Cloyd |
| المصدر: | Journal of Gastrointestinal Surgery. 21:636-646 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Cost-Benefit Analysis, medicine.medical_treatment, 030230 surgery, Risk Assessment, Gastroenterology, Body Mass Index, Pancreaticoduodenectomy, law.invention, Pancreatic Fistula, 03 medical and health sciences, chemistry.chemical_compound, Pancreatectomy, Postoperative Complications, 0302 clinical medicine, Randomized controlled trial, Risk Factors, law, Internal medicine, medicine, Humans, Aged, Pancreatic duct, business.industry, Patient Selection, Pancreatic Ducts, Organ Size, Perioperative, Middle Aged, medicine.disease, Hormones, Pasireotide, Surgery, medicine.anatomical_structure, chemistry, Pancreatic fistula, 030220 oncology & carcinogenesis, Relative risk, Female, Somatostatin, business, Body mass index |
| الوصف: | In a randomized trial, pasireotide significantly decreased the incidence and severity of postoperative pancreatic fistula (POPF). Subsequent analyses concluded that its routine use is cost-effective. We hypothesized that selective administration of the drug to patients at high risk for POPF would be more cost-effective. Consecutive patients who did not receive pasireotide and underwent pancreatoduodenectomy (PD) or distal pancreatectomy (DP) between July 2011 and January 2014 were distributed into groups based on their risk of POPF using a multivariate recursive partitioning regression tree analysis (RPA) of preoperative clinical factors. The costs of treating hypothetical patients in each risk group were then computed based upon actual institutional hospital costs and previously published relative risk values associated with pasireotide. Among 315 patients who underwent pancreatectomy, grade B/C POPF occurred in 64 (20%). RPA allocated patients who underwent PD into four groups with a risk for grade B/C POPF of 0, 10, 29, or 60% (P |
| تدمد: | 1873-4626 1091-255X |
| DOI: | 10.1007/s11605-016-3340-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b4397973b87f33b0004ce57ade6753 https://doi.org/10.1007/s11605-016-3340-7 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....07b4397973b87f33b0004ce57ade6753 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18734626 1091255X |
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| DOI: | 10.1007/s11605-016-3340-7 |