Increased risk of community-acquired pneumonia in COPD patients with comorbid cardiovascular disease
| العنوان: | Increased risk of community-acquired pneumonia in COPD patients with comorbid cardiovascular disease |
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| المؤلفون: | Chin-Shui Yeh, Ching-Hsiung Lin, Sheng-Hao Lin, Diahn-Warng Perng, Woei-Horng Chai, Ching-Pei Chen, Jeremy J.W. Chen, Chew-Teng Kor, Shih-Lung Cheng |
| المصدر: | International Journal of Chronic Obstructive Pulmonary Disease |
| بيانات النشر: | Dove Medical Press, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, community-acquired pneumonia, Comorbidity, Kaplan-Meier Estimate, Medical Records, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Community-acquired pneumonia, cardiovascular disease, Adrenal Cortex Hormones, Risk Factors, Cumulative incidence, 030212 general & internal medicine, Original Research, Aged, 80 and over, COPD, Incidence (epidemiology), Incidence, Hazard ratio, General Medicine, Middle Aged, CVD, CAP, Bronchodilator Agents, Community-Acquired Infections, Cardiovascular Diseases, Female, medicine.medical_specialty, Taiwan, International Journal of Chronic Obstructive Pulmonary Disease, Risk Assessment, chronic obstructive pulmonary disease, 03 medical and health sciences, Internal medicine, Administration, Inhalation, medicine, Humans, Risk factor, Aged, Proportional Hazards Models, Retrospective Studies, Chi-Square Distribution, business.industry, Proportional hazards model, Pneumonia, medicine.disease, respiratory tract diseases, 030228 respiratory system, Multivariate Analysis, inhaled corticosteroids, business |
| الوصف: | Sheng-Hao Lin,1,2 Diahn-Warng Perng,3,4 Ching-Pei Chen,5,6 Woei-Horng Chai,1 Chin-Shui Yeh,1 Chew-Teng Kor,7 Shih-Lung Cheng,8,9 Jeremy JW Chen,2,* Ching-Hsiung Lin1,10,11,* 1Department of Internal Medicine, Division of Chest Medicine, Changhua Christian Hospital, Changhua, 2Institute of Biomedical Sciences, National Chung Hsing University, Taichung, 3Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, 4School of Medicine, National Yang-Ming University, Taipei, 5Department of Internal Medicine, Division of Cardiology, Changhua Christian Hospital, 6Department of Beauty Science and Graduate Institute of Beauty Science Technology, Chien-Kuo Technology University, 7Department of Internal Medicine, Internal Medicine Research Center, Changhua Christian Hospital, Changhua, 8Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, 9Department of Chemical Engineering and Materials Science, Yuan Ze University, Zhongli City, Taoyuan, 10Department of Respiratory Care, College of Health Sciences, Chang Jung Christian University, Tainan, 11School of Medicine, Chung Shan Medical University, Taichung, Taiwan *These authors contributed equally tothiswork Background and objective: COPD patients with community-acquired pneumonia (CAP) have worse clinical outcomes, as compared to those without COPD. Cardiovascular disease (CVD) is a common comorbidity for COPD patients. Whether COPD with comorbid CVD will increase the risk of CAP is not well investigated. The incidence and factors associated with CAP in COPD patients with and without CVD were analyzed. Methods: The medical records of patients with newly diagnosed COPD between 2007 and 2010 were reviewed. The patients’ characteristics, medical history of CVD, occurrence of CAP, and type of medication were recorded. Kaplan–Meier curves were used to assess the differences in cumulative incidence of CAP. Cox’s proportional hazards regression model was used to determine the adjusted hazard ratios with 95% confidence intervals in relation to factors associated with CAP in COPD patients with and without CVD. Results: Among 2,440 patients, 475 patients (19.5%) developed CAP during the follow-up period. COPD patients who developed CAP were significantly older, had lower forced expiratory volume in 1 second, frequent severe exacerbation and comorbid CVD, as well as received inhaled corticosteroid (ICS)-containing therapy than those without CAP. The cumulative incidence of CAP was higher in COPD patients with CVD compared to those without CVD. Patients who received ICS-containing therapy had significantly increased risk of developing CAP compared to those who did not. Conclusion: For patients with COPD, comorbid CVD is an independent risk factor for developingCAP. ICS-containing therapy may increase the risk of CAP among COPDpatients. Keywords: chronic obstructive pulmonary disease, COPD, community-acquired pneumonia, cardiovascular disease, inhaled corticosteroids, CAP, CVD |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1178-2005 1176-9106 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b1fa7ddc8e277f10dbcc2edc38087a http://europepmc.org/articles/PMC5147399 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....07b1fa7ddc8e277f10dbcc2edc38087a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11782005 11769106 |
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